B.S.University of Massachusetts, M.S.,
Ph.D.,Boston University School of Medicine,
Neuroscience Institute Director, MUSC
Admiral Pihl Chair
Director, Stroke Program of South Carolina
Associate Director, South Carolina Spinal Cord Injury Center
Department of Physiology and Neuroscience
Medical University of South Carolina, Charleston, SC
kindyms@musc.edu
My research focus is on the developing and aging nervous system of humans and marine mammals. Specific emphasis is directed towards neuroinflammatory diseases. Recent work has begun to examine the role of environmental toxins on the nervous system in the mouse models. Dissection of the signaling pathways that lead to apoptotic and non-caspase mediated cell death are the important aspects of this work and may lead to the development of therapeutic agents. Other areas of our work are focused on understanding the neurotoxic effects of marine biotoxins originating from dinoflagellates. Both in vitro and in vivo models are used to study the effects of these toxins in the nervous system. Additionally, our aim is to address human health problems through chemical and biological research on compounds derived from marine organisms. Using cell culture and mouse models of human diseases, we are screening chemical components derived from these organisms to identify potential new therapeutic agents for treating human diseases, such as stroke and Alzheimer’s disease.
HONORS AND AWARDS:
1998 Methods in Enzymology Article
1990 Articles Alert Review in The Scientist
1989-present Grant Awards (Section, ante)
1987 Anna Fuller Fund Postdoctoral Fellowship, Salk Institute
1986 Department of Biochemistry Research Assistant Fellowship, Boston
University School of Medicine
1983-86 National Institute of Health Training Grant, Boston University
School of Medicine
1982 Research Fellowship, Department of Biochemistry, Boston University
School of Medicine
1980 Jackson Laboratory Summer Research Fellowship, Bar Harbor, Maine
PUBLICATIONS:
Stepp, M.A., Kindy, M.S., Franzblau, C. and Sonenshein, G.E. (1986)
Cloning of type III collagen and expression in aortic smooth muscle
cells. Annals N.Y. Acad. Sci. 460:510-513
.
Stepp, M.A., Kindy, M.S., Franzblau, C. and Sonenshein, G.E. (1986)
Complex regulation of collagen gene expression in cultured bovine aortic
smooth muscle cells. J. Biol. Chem. 261:6542-6548.
Dean, M., Levine, R.A., Ran, W., Kindy, M.S., Sonenshein, G.E. and
Campisi, J. (1986) Regulation of c-myc transcription and mRNA abundance
by serum growth factors and cell contact. J. Biol. Chem. 261:9161-9166.
Kindy, M.S. and Sonenshein, G.E. (1986) Regulation of oncogene
expression in cultured aortic smooth muscle cells: Post-transcriptional
control of c-myc mRNA. J. Biol. Chem. 261:12865-12868.
Kindy, M.S., McCormack, J.E., Buckler, A.J., Levine, R.A. and Sonenshein,
G.E. (1987) Independent regulation of transcription of the two strands
of the c-myc gene. Mol. Cell. Biol. 7:2857-2862
Kindy, M.S., Chang, C.J. and Sonenshein, G.E. (1988) Serum deprivation
of vascular smooth muscle cells enhances collagen gene expression. J.
Biol. Chem. 263:11426-11430.
Glenney, J.R., Kindy, M.S. and Zokas, L.M. (1989) Isolation of a novel
Ca++-binding protein with sequence similarity to s-100 but having a
distinct tissue distribution. J. Cell Biol. 108:569-578.
Reilly, C.F., Kindy, M.S., Brown, K.E., Rosenberg, R.D and Sonenshein,
G.E.. (1989) Heparin prevents vascular smooth muscle cell progression
through the G1 phase of the cell cycle. J. Biol. Chem. 264:6990-6995.
Kindy, M.S. and Verma, I.M. (1990) Developmental expression of the
xenopus laevis c-fos proto-oncogene. Cell Growth & Differentiation,
1:27-37.
Dempsey, R.J., Carney, J.M. and Kindy, M.S. (1990) Inducible ornithine
decarboxylase expression in brain subject to vasogenic edema after
transient ischemia: relationship to c-fos gene expression. Acta
Neurochir. Suppl. Wien. 51:189-191.
Kindy, M.S. Carney, J.P., Dempsey, R.J. and Carney, J.M. (1991) Ischemic
induction of proto-oncogene expression in the gerbil brain. J. Molec.
Neurosci. 2:217-228
Mann, J.S., Kindy, M.S., Edwards, D.R., and Curry, T.E. Jr. (1991)
Hormonal regulation of matrix metalloproteinase inhibitors in rat
granulosa cells and ovaries. Endocrinology. 128:1825-1832.
Carney, J.M., Carney, J.P., Tolliver, B. and Kindy, M.S. (1991)
Selective effects of methamphetamine on mRNA expression and behavior in
gerbils. J. Neuropharm. 30:1011-1019.
Kindy, M.S., Brown, K.E., and Sonenshein, G.E. (1991) Regulation of
expression of the growth state-related genes 2F1 and 2A9 during entry of
quiescent smooth muscle cells into the cell cycle. J. Cell. Biochem.
46:345-350.
Kindy, M.S., Srivatsan, M. and Peretz, B. (1991) Age-related
differential expression of neuropeptide mRNAs in Aplysia. Neuroreport.
2:465-468.
Dempsey, R.J., Carney, J.M., Kindy, M.S. (1991) Modulation of Ornithine
Decarboxylase mRNA Following Transient Ischemia in the Gerbil Brain. J.
Cerebral Blood Flow Metabolism. 11:979-985.
Materre, W.F., Kindy, M.S., Carney, J.M., Landrum, R.W., Strodel, M.D.
(1991) Induction of the proto-oncogene c-fos and recovery of cytosolic
ATP in reperfused liver after transient warm ischemia; effect of nitrone
free-radical spin-trap agents. Surgery. 110:184-191
.
Osborne, J.G., Kindy, M.S., and Hauser, K.F. (1991) Proenkephalin mRNA
expression in developing rat cerebellar cortex: expression levels
coincide with maturational gradients in purkinje cells. Developmental
Brain Res. 63:63-70.
Combs, D., Dempsey, R.J., Donaldson, D., and Kindy, M.S. (1992)
Hyperglycemia suppresses c-fos mRNA expression following transient
cerebral ischemia in gerbils. J. Cerebral Blood Flow and Metabolism.
12:169-172.
Bhat, N., Hauser, K.F., Kindy, M.S. (1992) Cell proliferation and protooncogenes c-fos and c-jun induction in oligodendroglial progenitor
cells. J. Neurosci. Res. 32:340-349.
Brown, K., Kindy, M.S., and Sonenshein, G.E. (1992) Cell cycle
regulation of the c-myb proto-oncogene in calf smooth muscle cells. J.
Biol. Chem. 267:4625-4630.
Kindy, M.S., Bhat, A., and Bhat, N. (1992) Transient ischemia increases
glial fibrillary acid protein and vimentin gene expression in the gerbil
neocortex, striatum and hippocampus. Mol. Brain Res. 13:199-206.
Heistand, D., Haley, B., and Kindy, M. (1992) Phosphorylation changes
following transient ischemia in the gerbil brain. J. Neurol. Sci.
113:31-37.
Heistand, D. and Kindy, M.S. (1992) Calcium/calmodulin dependent protein
kinase II mRNA in the gerbil brain after cerebral ischemia. Neurosci.
Lett. 144:75-78.
Campos-Gonzales, R., and Kindy, M.S. (1992) Tyrosine phosphorylation of
MAP kinase after transient ischemia in the gerbil brain. J. Neurochem.
59:1955-1958.
Fanti, P., Kindy, M., Mohpatra, S., Klein, J., Colombo, G., Malluche, H.
(1992) Dose-dependent effects of aluminum on osteocalcin synthesis in
osteoblastic like Ros 17/2 cells in culture. Amer. J. Phys. Endo. Metab.
Am. J. Phys. 263:E1113-E1118.
Kindy, M.S. (1993) Inhibition of tyrosine phosphorylation prevents
delayed neuronal death following cerebral ischemia. J. Cerebral Blood
Flow Metabol. 13:372-377.
Mann, J.S., Kindy, M.S., Hyde, J.F., Clark, M.R., and Curry, T.E. (1993)
Role of protein synthesis, prostaglandins, and estrogen in rat ovarian
metalloproteinase inhibitor production. Biol. of Reprod. 48:1006-1013.
Witkowski, A., Daunert, S., Kindy, M.S., Bachas, L. (1993) Enzyme-linked
immunosorbent assay for an octapeptide based on a genetically engineered
fusion protein. Anal. Chem. 65:1147-1151.
de Beer, M.C., de Beer, F.C., McCubbin, W.D., Kay, C.M., and Kindy, M.S.
(1993) Structural prerequisites for amyloid fibril formation: A novel
mouse model. J. Biol. Chem. 268:20606-20612.
Osborne, J.G., Kindy, M.S., Spruce, B.A., and Hauser, K.F. (1993)
Ontogeny of proenkephalin mRNA and enkephalin peptide expression in the
cerebellar cortex of the rat: Spatial and temporal patterns of
expression follow maturational gradients in the external granular layer
and in Purkinje cells. Develop. Neurobiology. 76:1-12.
De Beer, M., Kindy, M.S., Lane, W.S., and de Beer, F.C. (1994) Structure
and expression of the mouse serum amyloid A5 gene. J. Biol. Chem.
269:4661-4667.
Kindy, M.S., Hu, Y., Dempsey, R.J. (1994) Blockade of ornithine
decarboxylase enzyme protects against ischemic brain damage. J. Cereb.
Blood Flow Metab. 14:1040-1045.
Kindy, M.S. (1994) Inhibition of the NMDA receptor using antisense
oligonucleotides prevents delayed neuronal death in cerebral ischemia.
Neurosci. Res. Commun. 14:175-183.
Garner, L.K., Mendelson, M., Albers, K.M., Kindy, M.S., and Davis, B.M.
(1994) The effects of activity on enkephalin and substance P mRNA in the
developing chick spinal cord. J. Comp. Neurol. 347:36-46.
Liao, F., Lusis, A.J., Berliner, J.A., Fogelman, A.M., Kindy, M.S., de
Beer, M.C., and de Beer, F.C. (1994) Serum amyloid A Protein Family:
Differential induction by oxidized lipids in mouse strains.
Arteriosclerosis and Thrombosis. 14:1475-1479.
De Beer, M.C., Yuan, T., Kindy, M.S., Roheim, P.S., Asztalos, B.F., and
DeBeer, F.C. (1995) Characterization of Constitutive Human Serum Amyloid
A Protein (SAA4) as an Apolipoprotein. J. Lipid Res. 36:526-534.
Banka, C., Curtiss, L., Black, A., DeBeer, M.C., Kindy, M.S., and DeBeer,
F.C. (1995) Serum Amyloid A Protein: Influence on HDL Mediates
Cholesterol Efflux. J. Lipid Res. 36:1058-1065.
Kindy, M.S., King, A.R., Perry, G., de Beer, M.C., de Beer, F.C. (1995)
Association of Apolipoprotein E with murine AA amyloid. Lab. Invest.
73:469-475.
Kindy, M.S., de Beer, F.C., Marksbery, W.R., Pras, M., Pras, E.,
Kastner, D., Kyle, R., Skinner,M., Solomon, A., Woo, P. (1995)
Apolipoprotein E isotypes in systemic amyloidoses. Amyloid. 2:159-162.
Holtz, M.L., Kindy, M.S., Craddock, S., Moore, R.W., Pettigrew, L.C.
Induction of PGH synthase and c-fos mRNA during early reperfusion of
ischemic rat brain. (1996) Mol. Brain Research, 35:339-343.
De Beer, M.C., de Beer. F.C., Gerardot, C.J., Cecil, D.R., Webb, N.R.,
Goodson, M.L., Kindy, M.S. Structure of the mouse Saa4 gene and its
linkage to the serum amyloid A gene family. Genomics (1996) 34:139-142.
Bruce, A.J., Boling, W., Kindy, M.S., Peschon, J., Kraemer, P.J.,
Carpenter, M.K., Holtsberg, F.W., Mattson, M.P. Altered neuronal and
microglial responses to excitotoxic and ischemic brain injury in mice
lacking TNF receptors. (1996) Nature Med. 2:788-794.
Soto, C., Kindy, M.S., Baumann, M., Frangione, B. Inhibition of
Alzheimer’s amyloidosis by peptides that prevent -sheet conformation.
(1996) Biochem. Biophys. Res. Commun. 226:672-680.
Adibhatla, R.M., Baskaya, MK, Kindy, M.S., Maley, M., Dempsey, R.J.
Beneficial effects of S-adenosyl-L-methionine on blood-brain barrier
breakdown and neuronal survival after transient cerebral ischemia in
gerbils. (1997) Mol. Brain Res. 44:134-138.
Webb, NR, deBeer, MC, van der Westhuyzen, DR, Kindy, MS, Banka, CL,
Rader, DJ, deBeer, FC. Adenoviral vector-mediated overexpression of
serum amyloid A in apoAI deficient mice. (1997) J. Lipid Res.
34:1583-1590.
Keller JN, Kindy MS, Holtsberg FW, St Clair DK, Yen HC, Germeyer A,
Steiner S, Bruce-Keller AJ, Hutchins JB, Mattson MP. Mitochondrial
manganese superoxide dismutase prevents neural apoptosis and reduces
ischemic brain injury:suppression of peroxynitrate production, lipid
peroxidation and mitochondrial dysfunction. J Neurosci 1998; 18:687-697.
Mayeux R, et al. Utility of the apolipoprotein E genotype in the
diagnosis of Alzheimer’s disease. New Engl J Med 1998, 338:506-511
.
Kindy, M.S., Rader, D.J. Reduction in amyloid A amyloid formation in
apolipoprotein E deficient mice. American Journal of Pathology, 1998,
152:1387-1395.
Kindy, M. S., A. R. King, J. Yu, C. Gerardot, J. Whitley and F. C. de
Beer. Adenoviral expression of murine serum amyloid a proteins to study
amyloid fibrillogenesis. Biochemical J. 1998, 332:721-728.
Houdi, AA, Dasgupta, R., Kindy, M. Brain opioids in nicotine long-term
use and its withdrawal. Brian Res. 1998 Jul 20;799(2):257-63.
Gary DS, Bruce-Keller AJ, Kindy MS, Mattson MP Ischemic and excitotoxic
brain injury is enhanced in mice lacking the p55 tumor necrosis factor
receptor. J Cereb Blood Flow Metab 1998 Dec;18(12):1283-7.
Kirschner, D.A., Elliot-Bryant, R., Szumowski, K.E., Gonnerman, W.A.,
Kindy, M.S., Sipe, J.D., Cathcart, E. In vitro amyloid fibril formation
by synthetic peptides corresponding to the amino terminus of mouse
apoSAA isoforms from amyloid-susceptible and amyloid-resistant mice. J.
Struc. Biol. 1998 124:88-98.
Ramanathan, S., Lewis, J.C., Kindy, M.S., Daunert, S., Heterogeneous
bioluminescence binding assay for an octapeptide using recmobinant
aequorin. Anal. Chim, Acta, 1998, 369:181-188
.
Keller, J.N., Hanni, K.B., Gabbita, S.P., Friebe, V., Mattson, M.P.,
Kindy, M.S. Oxidized low density lipoprotein increase reactive oxygen
species formation in microglia and astrocyte cell lines. Brain. Res.
1999,830:10-15.
Yu, Z., Zhou, D., Bruce-Keller, A.J., Kindy, M.S., Mattson, M.P. Lack of
the p50 subunit of nuclear factor-kappaB increases the vulnerability of
hippocampal neurons to excitotoxic injury. J. Neurosci. 1999,
19:8856-65.
Rao, A.M., Hatcher, J.F., Kindy, M.S., Dempsey, R.J. Arachidonic acid
and leukotriene C4: role in transient cerebral ischemia of gerbils.
Neurochem. Res. 1999, 24:1225-32
.
Smith, C.D., Andersen, A.H., Krysio, R.J., Schmitt, F.A., Kindy, M.S.,
Blonder, L.X., Avison, M.J. Altered brain activation in cognitively
intact individuals at high risk for Alzheimer’s disease. Neurology 1999,
53:1391-1396.
Kindy, M.S., Yu, J., Guo, J.T., Zhu, H. Apolipoprotein Serum Amyloid A
in Alzheimer’s disease. J. Alzheimer’s Disease. 1999, 1:155-167.
Mattson, M.P., Zhu, H., Yu, J., Kindy, M.S. Presenilin-1 mutation
increases neuronal vulnerability to focal ischemia In vivo and to
hypoxia and glucose deprivation in cell culture: involvement of
perturbed calcium homeostasis. J Neurosci 2000, 20:1358-1364.
Guo Z, Kindy MS, Kruman I, Mattson MP. ALS-linked Cu/Zn-SOD mutation
impairs cerebral synaptic glucose and glutamate transport and
exacerbates ischemic brain injury. J Cereb Blood Flow Metab. 2000,
20:463-8.
Yu, J., Guo, J.-T., Zhu, H. Kindy, M.S. Amyloid formation in the rat:
adenoviral expression of mouse serum amyloid A proteins. Amyloid, 2000,
7:32-40.
Keller, J.N., Hanni, K.B., Kindy, M.S. Oxidized high-density lipoprotein
induces neuron death. Exp. Neurol. 2000 161:621-30..
Keller, J.N. Lauderback, C.M., Butterfield, D.A., Kindy, M.S., Yu, J., Markesbery, W.R. Potential role for apolipoprotein E in maintaining
synaptic homeostasis. J Neurochem. 2000 74:1579-86.
Kindy, M.S., Yu, J., de Beer, M.C., de beer, F.C. Overexpression of
acute phase (SAA2) and constitutive (SAA4) serum amyloid A isotypes:
influence on lipoprotein profiles. Arterio. Thromb. Vasc. Biol. 2000,
20:1543-1550.
Yan, S.D., Zhu, H., Zhu, A., Golabek, A., Wolozin, B., Roher, A., Yu,
J., Chaney, M., Soto, C., Schmidt, A.M., Stern, D., Kindy, M.S. RAGE and amyloid fibrils: receptor-dependent signaling by -sheet fibrils
mediates cellular stress in amyloidosis. Nature Medicine, 2000,
6:643-651.
De Villiers, W.J.S., Varilek, G.W., de beer, M.C., Guo, J.T., Kindy,
M.S. Increased serum amyloid A levels reflect colitis severity and
precede amyloid formation in IL-2 deficient mice. Cytokine 2000,
12:1337-47.
Keller, J.N., Huang, F.F., Zhu, H., Yu, J., Ho, Y.-S., Kindy, M.S.
Oxidative stress-associated impairment of proteosome activity during
ischemia-reperfusion injury. J. Cereb. Blood Flow Metab. 2000,
20:1467-73.
De Beer, F.C., Connell, P.M., Yu, J., Kindy, M.S., de Beer, M.C., Webb,
N.R., van der Westhuyzen, D.R. HDL modification by secretory
phospholipase A2 promotes SR-BI interaction and accelerates HDL
catabolism. J. Lipid Res. 2000, 41:1849-57.
Yu, J., Zhu, H., Guo, J.T., de Beer, F.C., Kindy, M.S. Expression of
Mouse Apolipoprotein SAA1.1 in CE/J Mice: Isoform Specific Effects on
Amyloidogenesis. Lab. Invest. 2000, 80:1797-1806.
Dubal, D.B., Zhu, H., Yu, J., Rau, S.W., Shughrue, P.J., Merchenthaler,
I., Kindy, M.S., Wise, P.M. Estrogen Receptor -, not -, is Critical in Estradiol-Mediated Neuroprotection against Stroke Injury. PNAS, 2001,
98:1952-1957.
Xie C, Lovell MA, Xiong S, Kindy MS, Guo J, Xie J, Amaranth V, Montine
TJ, Markesbery WR. Expression of glutathione-S-transferase isozyme in
the SY5Y neuroblastoma cell line increases resistance to oxidative
stress. Free Radic Biol Med. 2001, 31:73-81.
Lauderback CM, Hackett JM, Keller JN, Varadarajan S, Szweda L, Kindy M, Markesbery WR, Butterfield DA. Vulnerability of synaptosomes from apoE
knock-out mice to structural and oxidative modifications induced by A
beta(1-40): implications for Alzheimer's disease. Biochemistry. 2001,
40:2548-54.
Smith CD, Andersen AH, Kryscio RJ, Schmitt FA, Kindy MS, Blonder LX, Avison MJ.
Differences in functional magnetic resonance imaging activation by
category in a visual confrontation naming task. J. Neuroimaging. 2001,
11:165-70.
Ely, S., Ancsin, J.B., Kindy, M.S., Kisilevsky, R. Macrophage
acyl-CoA:Cholesterol acyltransferase activity is influenced by the
acute-phase apolipoprotein serum amyloid A. Amyloid. 2001, 8:169-181.
Zhu, H., Yu, J. and Kindy, M.S. Inhibition of Amyloidosis Using
Low-Molecular-Weight Heparins. Molec. Med. 2001, 7:517-522.
Wyss-Coray, T., Yan S.D., Kindy, M.S., Schmidt, A.M., Stern, D. Key
signaling pathways regulate the biological activities and accumulation
of amyloid-beta. Neurobiology of Aging. 2001;22:967-973.
Lauderback CM, Kanski J, Hackett JM, Maeda N, Kindy MS, Butterfield DA. Apolipoprotein E modulates Alzheimer's A(1-42)-induced oxidative damage
to synaptosomes in an allele-specific manner. Brain Res 2002:924:90-97.
Guo, J-T., Yu, J., Zhu, H., Grass, D., de Beer, F.C., Kindy, M.S.
Inflammation dependent cerebral deposition of serum amyloid A protein in
a mouse model of amyloidosis J. Neurosci, 2002, 22:5900-5909.
Smith CD, Andersen AH, Kryscio RJ, Schmitt FA, Kindy MS, Blonder LX, Avison MJ.
Women at risk for AD show increased parietal activation during a fluency
task. Neurology. 2002, 58:1197-202.
Rebeck GW, Kindy M, LaDu MJ. Apolipoprotein E and Alzheimer's disease:
the protective effects of ApoE2 and E3. J Alzheimers Dis. 2002,
4:145-54.
Estus S, Borchelt D, Kindy MS, Vassar R. Abeta deposition is essential
to AD neuropathology. J Alzheimers Dis. 2002, 4:133-8.
Webb NR, Cai L, Ziemba KS, Yu J, Kindy MS, Van Der Westhuyzen DR, De
Beer FC.The fate of HDL particles in vivo after SR-BI-mediated selective lipid
uptake. J Lipid Res. 2002, 43:1890-8.
Webb NR, de Beer MC, Yu J, Kindy MS, Daugherty A, van der Westhuyzen DR,
de Beer FC. Overexpression of SR-BI by adenoviral vector promotes
clearance of apoA-I, but not apoB, in human apoB transgenic mice. J
Lipid Res. 2002, 43:1421-8.
Hunter CL, Isacson O, Nelson M, Bimonte-Nelson H, Seo H, Lin L, Ford K,
Kindy MS, Granholm AC.Regional alterations in amyloid precursor protein
and nerve growth factor across age in a mouse model of Down's syndrome.
Neurosci Res. 2003 Apr;45(4):437-45.
Marr, RA, Rockenstien E, Mukherjee A, Hersh LB, Kindy MS, Gage F, Verma
IM and Masliah E. Neprilysin gene transfer reduces human amyloid
pathology in transgenic mice. J. Neurosci. 2003; 23:1992-1996.
Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch
D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt
AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M,
Stern D, Zlokovic B. RAGE mediates amyloid- peptide transport across
the blood-brain barrier, suppression of cerebral blood flow and
development of cerebral amyloidosis. Nature Medicine, 2003; 9:907-913.
Ellsworth J, Yu J, Kindy MS. Fibroblast growth factor18 reduces infarct
volumes and behavioral deficits after transient occlusion of the middle
cerebral artery in rats. Stroke 2003; 34:1507-1512.
Wu J, Zhu BB, Yu J, Zhu H, Qiu L, Kindy MS, Gu L, Seidel A, Li GM.In
vitro and in vivo modulations of benzo[c]phenanthrene-DNA adducts by DNA
mismatch repair system. Nucleic Acids Res. 2003, 31:6428-34.
Ellsworth JL, Garcia R, Yu J, Kindy MS. Time window of fibroblast growth
factor-18-mediated neuroprotection after occlusion of the middle
cerebral artery in rats. J. Cereb. Blood Flow Metab. 2004, 24:114-123.
Marr RA, Guan H, Rockenstein E, Kindy M, Gage FH, Verma I, Masliah E,
Hersh LB. Neprilysin regulates amyloid Beta peptide levels. J Mol
Neurosci. 2004;22:5-11.
Wang Y, Meng A, Lang H, Brown SA, Konopa JL, Kindy MS, Schmiedt RA,
Thompson JS, Zhou D. Activation of nuclear factor kappaB In vivo
selectively protects the murine small intestine against ionizing
radiation-induced damage. Cancer Res. 2004, 64:6240-6.
Sambamurti K, Granholm AC, Kindy MS, Bhat NR, Greig NH, Lahiri DK,
Mintzer JE. Cholesterol and Alzheimer's disease: clinical and
experimental models suggest interactions of different genetic, dietary
and environmental risk factors. Curr Drug Targets. 2004, 5:517-28.
Arancio O, Zhang HP, Yu J, Chen X, Lin C, Trinchese F, Battaglia F, Yan
SF, Stern A, Lue LF, Walker D, Roher A, Buttini M, Mucke L, Yi L, Kindy
M, Hyslop P, Stern D, and Yan SD. RAGE Potentiates Aß-induced
perturbation of neuronal function in transgenic mice, EMBO, 2004, 1-10.
Ertekin-Taner N, Ronald J, Feuk L, Prince J, Tucker M, Younkin L, Hella
M, Jain S, Hackett A, Scanlin L, Kelly J, Kihiko-Ehman M, Neltner M,
Hersh L, Kindy M, Markesbery W, Hutton M, Andrade M, Petersen RC,
Graff-Radford N, Estus S, Brookes AJ, Younkin SG. Elevated amyloid
{beta} protein (A{beta}42) and late onset Alzheimer's disease are
associated with single nucleotide polymorphisms in the urokinase-type
plasminogen activator gene. Hum Mol Genet. 2005, 14:447-460.
Suzuki S, Gerhold LM, Böttner M, Rau SW, Cruz CD, Yang E, Zhu H, Yu J,
Cashion AB, Kindy MS, Merchenthaler I, Gage FH, Wise PM. Estradiol
Enhances Neurogenesis After Ischemic Brain Injury:Roles of Estrogen
Receptor and Science, Submitted.
Pettigrew, LC, Holtz, ML, Li, Y, Yu, J, Kryscio, RJ, Craddock SD,
Godwin, S, Kovatcheva-Ivanova, S, Grass, DS, and Kindy, MS. Focal
Cerebral Ischemia in the TNF-Transgenic Rat. Stroke, submitted.
Keller, J.N., Hanni, K.B., Markesbery, W.R., Kindy, M.S. Oxidized
lipoproteins and microglial activation. Brain Research. Submitted.
Kindy, M.S., Yu, J., Guo, J-T., Snowdon, D. Brain expression of
apolipoprotein SAA in Alzheimer’s disease. Submitted, Brain Res.
Kindy, M.S., W. deVilliers, J. Yu, P. J. Gough, S. Gordon. Altered
levels of macrophage scavenger receptors in Alzheimer’s disease.
Submitted. J. Alz. Dis.
Yu, J., Zhu, H., Guo, J.T., Hersh, L.B., Kindy, M.S. Inhibition of neprilysin increases amyloid deposition in APP transgenic mice.
Submitted to Brain Res.
Yu J, Zhu H, Guo JT, Mucke L, Hersh LB, Kindy MS. Neprilysin modulates
A peptide levels and amyloid deposition in APP transgenic mice. Brain
Res 2002; submitted.
Yu J, Zhu H, Guo JT, Hersh LB, Kindy MS. Accelerated A amyloid
deposition in neprilysin gene-inactivated mice. Nature 2002; submitted
ARTICLES OR CHAPTERS IN BOOKS:
Kindy, M.S. and Verma, I.M. (1988) Inhibition of c-fos gene expression
does not alter the differentiation pattern of PC12 cells. In Current
Communications in Molecular Biology: Antisense RNA and DNA. Melton, D.,
ed. pp 129-133.
Carney, J.M., Kindy, M.S., Smith, C.D., Wood, K., Tatsuno, T., Wu, J.F.,
Landrum, W.R., and Floyd, R.A. (1993) Gene expression and functional
changes after acute ischemia: Age-related differences in outcome and
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