Professor, Department of Medicine, Division of Rheumatology and Immunology
MUSC, Charleston, SC
M.D., Southwestern Medical College
gilkeson@musc.edu
Studies of autoimmunity and the triggers of systemic autoimmune disease. My laboratory is primarily interested in studies of autoimmunity and the triggers of systemic autoimmune disease. One of the triggers we are studying is environmental exposures. Two specific areas of investigation are the studies of the effects of trichloroethylene on lupus prone mice and case control studies of genetic/environmental exposures in patients with SLE compared to matched controls. The TCE studies are being conducted in collaboration with Dr. Margie Peden-Adams.
Publications:
Mishra N, Reilly CM, Brown DR, Ruiz P,
Gilkeson GS. Histone deacetylase inhibitors modulate renal disease in
the MRL-lpr/lpr mouse. J Clin Invest. 111:539-552, 2003.
Reilly C, Farrelly L, Viti D, Redmond S, Hutchison F, Ruiz P, Manning P,
Connor J, Gilkeson G. Modulation of renal disease in MRL/lpr mice by
pharmacologic inhibition of inducible nitric oxide synthase. Kidney Int.
61:839-846, 2002.
Parks CG, Cooper GS, Nylander-French LA, Sanderson WT, Dement JM, Cohen
PL, Dooley MA, Treadwell EL, St Clair E, Gilkeson GS, Hoppin JA, Savitz
DA. Occupational exposure to crystalline silica and risk of systemic
lupus erythematosus. Arthritis Rheum. 46:1840-50, 2002.
Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS. Hormonal
and reproductive risk factors for development of systemic lupus erythematosus: Results of a population-based, case-control study.
Arthritis Rheum. 46:1830-9, 2002.