Wayne R. Fitzgibbon


Assistant Professor, Department of Medicine
MUSC, Charleston, SC

Ph.D., University of Newcastle, Australia

 fitzgiwr@musc.edu
Research:
Integration of physiological and molecular approaches to understanding the mechanisms involved in the regulation of renal function in elasmobranch fish and in mammals. Our research with elasmobranchs is focused on the renal mechanisms involved in volume- and osmo-regulation, specifically the role of urea transporters and aquaporins. Recent studies have involved the determination of parameters of renal function in stingrays, as well as, the cloning and identification of several isoforms of urea transporters from batoid elasmobranchs. New projects include the identification of sites within the kidney at which urea transporter gene and protein expression occurs.		  

Publications:
 

Janech, M.G., Fitzgibbon, W.R., Ploth, D.W., Lacy, E.R. and Miller, D.H. (2003). Effect of Environmental Salinity on Plasma Composition and Renal Function of the Atlantic Stingray, a Euryhaline Elasmobranch. in preparation

Janech, M.G., Cwengros, E., Gefroh, H., Sulikowski, J.A., Ploth, D.W. and Fitzgibbon, W.R. (2003). A Common Renal Urea Transporter Isoform is Expressed in the Kidneys of Elasmobranchs. in preparation

Janech, M.G., Fitzgibbon, W.R., Nowak, M., Miller, D.H. and Ploth, D.W. (2003). Identification of a Second Urea transporter Isoform in the Kidney of the Atlantic Stingray. in preparation

Janech, M.G., Fitzgibbon, W.R., Chen, R., Paul R.V., Nowak, M., Miller, D.H. and Ploth, D.W. (2003). Physiological and molecular characterization of a urea transporter from the kidney of the euryhaline Atlantic stingray, Daysatis sabina. American Journal of Physiology (Renal and Fluid Physiology) 284: F996-F1005.

Ullian, M.E., Gantt, B.J., Ford, A.K., Tholanikunnel, B.G., Spicer, E.K. and Fitzgibbon, W.R. (2003). Potential importance of glomerular citrate synthase activity in remnant nephropathy. Kidney International 63: 156-164.

Janech, M.G., Chen, R., Paul R.V., Nowak, M., McFee, W., Fitzgibbon, W.R. and Ploth, D.W. (2002) Physiological and molecular characterization of a urea transporter from the kidney of the short-finned pilot whale, Globcephala macrorhynchus American Journal of Physiology (Regulatory and Comparative Physiology) 282: R1490-R1500.