William S. Baldwin, Ph.D.        

 Associate Professor, Institute of Environmental Toxicology
Clemson University, Clemson SC

Ph.D., North Carolina State University

Baldwin@clemson.edu 

Research:

My research focuses on toxicant-induced changes in gene expression mediated through the nuclear receptors, CAR and PXR.  I am particularly interested in endocrine disrupting chemicals and their ability to activity CAR and PXR and in turn induce P450 expression or cause P450-synergized toxicity of pesticides and other environmental chemicals.  This work also includes the study of chemical mixtures on CAR and PXR activity because we are not exposed to only one chemical at a time.
My laboratory is also involved in the Fundulus and Daphnia Genomics Consortiums.  I am currently annotating the P450 family in the Daphnia pulex genome.  We also investigate global changes in gene expression caused by reproductive or aquatic toxicants in collaboration with Dr. Lisa Bain.  We are using Fundulus heteroclitus (mummichog) microarrays as a biomarker for determining the efficacy of remediation at coastal Superfund sites.

Publications:

Baldwin, W.S., Marko, P.B., Nelson, D.R. The cytochrome P450 (CYP) gene superfamily in Daphnia pulex.  BMC Genomics.  Submitted and in revision (accepted with minor revisions).

Burnett, K.G., Bain, L.J., Baldwin, W.S., Callard, G.V., Cohen, S., Di Giulio, R.T., Evans, D.H., Gomez-Chiarri, M., Hahn, M.E., Hoover, C.A., Karchner, S.I., Katoh, F., MacLatchy, D.L., Marshall, W.S., Meyer, J.N., Nacci, D.E., Oleksiak, M.F., Rees, B.B., Singer, T.D., Stegeman, J.J., Towle, D.W., Van Veld, P.A., Vogelbein, W.K., Whitehead, A., Winn, R.N., Crawford, D.L. (2007)  Fundulus as the premier teleost model in environmental biology:  Opportunities for new insights using genomics.  Comp Biochem Physiol D: Genomics and Proteomics., 2: 257-286.  

Saldivar, S.J., Lopez, D., Feldman, R.A., Jacobs, R., de la Rosa, A., Terreros, D., Baldwin, W.S. (2007) COX-2 overexpression as a biomarker of cervical carcinogenesis: a pilot study.  Gynecol Oncol., 107: S155-S162. 

Hernandez, J.P., Huang, W., Chapman, L.M., Chua, S., Moore, D.D, Baldwin, W.S. (2007) The environmental estrogen, nonylphenol, activates the constitutive androstane receptor (CAR).  Toxicol. Sci., 98: 416-426.   

Roling, J.A., Bain, L.J., Gardea-Torresdey, J., Key, P.B., Baldwin, W.S. (2007) Using mummichog (Fundulus heteroclitus) arrays to monitor the effectiveness of remediation at a superfund site in Charleston, South Carolina.  Environ Toxicol Chem., 26: 1205-1213.

Hernandez, J.P., Chapman, L.M., Kretschmer, X.C., Baldwin, W.S.  (2006) Sexually dimorphic P450 induction in FVB/NJ mice following nonylphenol treatment.  Toxicol. Appl. Pharmacol., 216:  186-196.

Roling, J.A., Bain, L.J., Gardea-Torresdey, J., Bader, J., Baldwin, W.S.  (2006) Hexavalent chromium reduces juvenile growth and alters gene expression in Fundulus heteroclitus.  Environ. Toxicol. Chem., 25: 62-70. 

Roling, J.A., Baldwin, W.S.  (2006) Alterations in hepatic gene expression by trivalent chromium in Fundulus heteroclitus.  Mar Environ Res., 62:  S122-S127.

Gonzalez H.O., Roling, J.A., Baldwin W.S., Bain L.J. (2006) Physiological changes and differential gene expression in mummichogs (Fundulus heteroclitus) exposed to arsenic, Aquat. Toxicol., 77:43-52.

Acevedo, R., Villanueva, H., Parnell, P.G., Chapman, L.M., Gimenez, T., Gray, S.L., Baldwin, W.S. (2005) The contribution of hepatic steroid metabolism to serum estradiol and estriol concentrations in nonylphenol treated MMTVneu mice and its potential effects on breast cancer incidence and latency.  J. Appl. Toxicol., 25, 339-353.