Lisa J. Bain, Ph.D. Associate Professor Clemson University, Clemson SC Dept. of Biological Sciences Ph.D., North Carolina State University Lbain@clemson.edu
Research: Environmental toxicology and marine functional genomics. Research focuses on examining altered gene expression in fish after exposure to contaminants such as chromium, arsenic, and polycyclic aromatic hydrocarbons. We are interested in ascertaining what genes are being altered, what the resulting consequence or cost is to the organism, and whether these genes can be used as biomarker probes to assess exposure to other contaminants. The current project is specifically examining environmentally realistic concentrations of arsenic to ascertain its mechanism of developmental toxicity.
Publications: 1. Tribull TE, Bruner RH, and Bain LJ (2003) The Multidrug Resistance-Associated Protein 1 (MRP1/ABCC1) transports methoxychlor and protects the seminiferous epithelium from injury, Toxicology Letters, 142:61-70. 2. Bain LJ and Feldman RA (2003) Altered expression of sulfotransferases, glucuronosyltransferases, and MRP transporters in FVB/mrp1-/- mice, Xenobiotica, 33:1173-1184. 3. Maples NL and Bain LJ (2004) Trivalent chromium alters gene expression in the mummichog (Fundulus heteroclitus), Environmental Toxicology and Chemistry, 23:626-631. 4. Peterson JSK and Bain LJ (2004) Differential gene expression in anthracene-exposed mummichogs (Fundulus heteroclitus), Aquatic Toxicology, 66:345-355. 5. Roling JA, Bain LJ, and Baldwin WS (2004) Differential gene expression in mummichogs (Fundulus heteroclitus) following treatment with pyrene:  comparison to a creosote contaminated site, Marine Environmental Research, 57:355-395.  6. Belinsky MG, Dawson PA, Shchaveleva I, Bain LJ, Wang R, Ling V, Chen Z-S, Grinberg A, Westphal H, Klein-Szanto A, Lerro A, and Kruh GD (2005) Analysis of the in vivo functions of Mrp3, Molecular Pharmacology, 68:160-168. 7. Gonzalez HO, Roling JA, Baldwin WS, and Bain LJ (2006) Physiological changes and differential gene expression in mummichogs (Fundulus heteroclitus) exposed to arsenic, Aquatic Toxicology, 77:43-52. 8. Roling JA, Bain LJ, Gardea-Torresdey J, Bader J, and Baldwin WS (2006) Hexavalent chromium reduces larvae growth and alters gene expression in Fundulus heteroclitus, Environmental Toxicology and Chemistry, 25:2725-2733. 9. Roling JA., Bain LJ, Gardea-Torresdey J, Key PB, and Baldwin WS (2007) Using Fundulus heteroclitus arrays to monitor the effectiveness of Superfund site remediation at Shipyard Creek in Charleston, SC. Environmental Toxicology and Chemistry, 26:1205-1213.   10. Burnett KG, Bain LJ, Baldwin WS, Callard GV, Cohen S, Di Giulio RT, Evans DH, Comez-Chiarri M, Hahn ME, Hoover CA, Karchner SI, Katoh F, MacLatchy DL, Marshall WS, Meyer JN, Nacci DE, Oleksiak MF, Rees BB, Singer TP, Stegeman JJ, Towle DW, Van Veld PA, Vogelbein WK, Whitehead A, Winn RN, and Crawford DL (2007) Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics, Comparative Biochemistry and Physiology part D 2: 257-286.

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