About the Project

The $10.9 million grant to establish a center in Lipidomics and Pathobiology will support MUSC investigators in their efforts to understand the role of a class of fatty molecules, known as sphingolipids in regulating cell growth, cell death and cell aging. The five-year Center of Biomedical Research Excellence (COBRE) grant is funded by the National Institutes of Health. Lina Obeid, Boyle professor of medicine and professor of biochemistry, is principal investigator for the grant.

With this grant, we hope to develop a premier center that defines the function of these fatty molecules in human disease, especially cancer, aging, neurologic disease and fungal pathogenesis," said Yusuf Hannun, M.D., Ralph F. Hirschmann chair and professor of biomedical research, deputy director of the Hollings Cancer Center and co-investigator on the grant.

"The functions of this abundant class of molecules has been an enigma," said Hannun, "and hence the name derived from the Greek Sphinx. The members of the COBRE group at MUSC have been at the frontiers of developing an understanding of how these molecules participate in regulating several fundamental aspects of human cell
function."

The center will emphasize the mentoring of junior faculty and the development of specific shared research facilities for use by the entire MUSC research community.

The project described is supported by NIH Grant Number 1 P20 RR17677 from the COBRE Program of the National Center for Research Resource

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