Quicklist
Scott Eblen, Ph.D.
BSB 313E; 792-1444
eblen@@musc.edu
| Date | Lectures | Flex | Instructor |
|---|---|---|---|
|
Thurs Aug 27 |
Molecular Structure |
Assignment 1 Distribution |
Beeson (beesonc) |
|
Fri Aug 28 |
Chemical Reactivity |
|
Beeson |
|
Mon Aug 31 |
Solvation and Electrostatics |
|
Dix (dixta) |
|
Tues Sept 1 |
Protein Folding and Stability |
Beeson/Isaacs |
|
|
Thurs Sept 3 |
Principles of X-ray Crystallography |
Davies
(davies) |
|
|
Fri Sept 4 |
Protein-Protein Interactions |
Hsu (hsuy) |
|
|
Tues Sept 8 |
Protein Modifications |
Eblen |
|
|
Thurs Sept 10 |
Protein Characterization/Proteomics |
|
Ball (balle) |
|
Fri Sept 11 |
Enzymes and Catalysis |
Krupenko
(krupenko) |
|
|
Mon Sept 14 |
Enzyme Kinetics |
Kinetics Questions |
Beeson |
| Tues Sept 15 | Protein Purification | Hennig (hennig) |
|
| Thurs Sept 17 | Proteomics/Informatics | Schwacke (schwacke) |
|
| Fri Sept 18 | Unit Exam |
General reading Prerequisite reading for this Unit are Chapters 2, 3, 6, 10.3, 10.4, 23.3 and 23.3 of Stryer's Biochemistry (6th Ed)
| Date | Lectures | Flex | Instructor |
|---|---|---|---|
|
Mon Sept 21 |
Introduction to Unit 1. History, 2. DNA structure |
x-ray diffraction of DNA | Davies |
|
Tues Sept 22 |
1. RNA structure | Hennig (hennig) |
|
|
Thurs Sept 24 |
1.
DNA replication 2. DNA replication (continued) |
Prep for presentations |
Brown |
|
Fri Sept 25 |
1. Recombination 2. DNA repair |
Prep for presentations | Brown |
|
Mon Sept 28 |
Student Presentations | Brown | |
|
Tues Sept 29 |
1. Transcription in prokaryotic genes 2. Mechanisms of transcriptional regulation in prokaryotes |
Cowart (cowartl) |
|
|
Thurs Oct 1 |
1. Genetic code 2. tRNA synthetases, translation |
|
Davies |
|
Fri Oct 2 |
1. Structure of the prokaryotic ribosome 2. Regulation of prokaryotic translation |
|
Davies |
|
Mon Oct 5 |
1. Catalytic RNA 2. RNA world hypothesis |
|
Davies |
| Tues Oct 6 | Techniques in nucleic acid research | Kurtz (kurtzdt) |
|
| Thurs Oct 8 | Pharmacogenetics | Kurtz | |
|
Fri Oct 9 |
Unit Exam |
General reading
Prerequisite: Chapters 4-7 of Molecular Biology of the Cell, 5th Ed, Alberts et al. Also useful are Chapters 4, 5, 28, 29 & 30 in Stryer, 6th ed.
| Date | Lectures | Flex | Instructor |
|---|---|---|---|
|
Mon Oct 12 |
1.
Biological thermodynamics & kinetics
2. Overview of bioenergetics & Redox |
Redox Questions |
Beeson |
|
Tues Oct 13 |
1. Lipids, bilayers &
membranes
2. Membrane biophysics |
|
Beeson |
|
Thurs Oct 15 |
1.
Transporters & channels: classes, function
2. Transporters & channels: techniques |
Transport Paper |
Covington |
|
Fri Oct 16 |
1. Regulation of catabolism versus anabolism 2. Signaling in regulation of metabolism |
|
Beeson |
|
Mon Oct 19 |
1. Mechanisms in Glycolysis 2. Gluconeogenesis |
Assignment 1 Due |
Davies (davies) |
|
Tue Oct 20 |
Structural Aspects of Regulation |
|
Davies |
|
Thu Oct 22 |
1. Citric Acid Cycle 2. Beta oxidation |
Seahorse Lab |
Lemasters (lemaste) |
|
Fri Oct 23 |
1. Electron transport chain 2. Biophysics of mitochondrial membranes |
|
Lemasters |
|
Mon Oct 26 |
1. Chemiosmotic energy transduction 2. Oxidative Phosphorylation |
Assignment 2 Due |
Lemasters |
| Tue Oct 27 | 1. Mitochondrial DNA 2. Mitochondrial Diseases |
Mito-DNA Paper | Chan (lamcf) |
| Thu Oct 29 | Integrative metabolism and metabolomics | Questions Overview | Beeson |
|
Fri Oct 30 |
Unit Exam |
|
General Reading for the Metabolism and Bioenergetics Unit
Lehninger (5th Ed) Chapter |
Stryer (6th Ed.) Chapter |
|
|---|---|---|
| Intro to Metabolism | 14 | 15 |
| Bioenergetics | 13 | |
| Lipids, membranes | 10 | 12 |
| Ion channels | 11 | 13 |
| Glycolysis | 14, 15 | 16 |
| TCA | 16 | 17 |
| Oxidative-Phosph | 19 | 18 |
| Fatty Acid Oxidation | 17 | 22 |
| Pentose Phosphate Pathway (HMP-shunt) |
15 | 20 |
| Gluconeogenesis | 14-15 | 16 |
| Glycogen Synthesis | 15 |
21 |
| Glycogen Catabolism | 15 |
21 |
| Fatty Acid Synthesis | 21 | 22 |
Useful Websites:
http://www.bmb.leeds.ac.uk/illingworth/oxphos/
http://www.esf.edu/efb/course/EFB325/default.htm
http://www.rpi.edu/dept/bcbp/molbiochem/MBWeb/mb1/MB1index.html
| Date | Lectures | Flex | Instructor |
|---|---|---|---|
|
Mon Nov 2 |
Overview of receptors & signaling I |
Methods of Studying Ligand:Receptor Interactions |
Rosenzweig (rosenzsa) |
|
Tues Nov 3 |
G protein coupled receptors |
Paper discussion (1) |
Blumer (blumerjb) |
|
Thur Nov 5 |
G proteins and their regulatory proteins |
Paper discussion (2) |
Blumer |
|
Mon Nov 9 |
Photoreceptors |
Paper discussion (3) |
Koutaios (koutalo) |
|
Tues Nov 10 |
Receptor tyrosine kinases |
Paper discussion (4) |
Rosenzweig |
|
Thur Nov 12 |
Protein: protein interactions in signal transduction |
Methods for identifying & studying protein interactions |
Ball (balle) |
|
Fri Nov 13 |
Receptor tyrosine kinase signaling to cell migration | Paper discussion (6) | Isaacs (isaacsj) |
| Mon Nov 16 | Protein kinases: MAP kinases | Paper discussion (7) | Eblen (eblen) |
| Tues Nov 17 | TGF- b Receptors and the Smads | Paper discussion (8) | Eblen |
| Thur Nov 19 | Signaling to apoptosis | Methods exercise | Voelkel-Johnson (johnsov) |
| Fri Nov 20 | Cell signaling in disease: cancer | Paper discussion (9) | Rosenzweig |
| Mon Nov 23 | Cell signaling in disease: Animal models of Cancer | Paper discussion (10) | Neumann (neumannc) |
|
Tues Nov 24 |
Unit Exam |
|
General reading
Prerequisite: Chapters 15, 17 & 23 of Molecular Biology of the Cell, 5th Ed, Alberts et al.
Specific Reading
Papers will be posted on WebCT as required
Dr. Donald Menick
Gazes/Strom Thurmond 203; 876-5045
menickd@@musc.edu
| Date | Lectures | Flex | Instructor |
|---|---|---|---|
|
Mon Nov 30 |
1. Eukaryotic Transcription/Regulation of Gene Expression I |
Discussion of student presentations |
Kyu-Ho Lee (leeh) |
|
Tues Dec 1 |
3: Integrating
Transcriptional Regulation Signaling Events
4: Epigenetic Regulation of Gene Expression |
Kyu-Ho Lee | |
|
Thurs Dec 3 |
5. HDAC's and HAT's Role in Gene Expression I |
Menick (menickd) | |
|
Fri Dec 4 |
7. RNA Interference I |
Menick | |
|
Mon Dec 7 |
9. Regulation of mRNA Processing and Localization I |
McDermott (mcdermp) | |
|
Tues Dec 8 |
11: Regulation of mRNA Stability and Translation |
Practice talks |
McDermott |
|
Thurs Dec 10 |
13. Viral Models for Molecular Biology I |
Practice talks |
Wright (wrightcf) Eisenman |
|
Fri Dec 11 |
Student presentations of research papers | ||
| Mon Dec 14 | Student presentations of research papers | ||
| Tues Dec 15 | Student presenations of research papers | ||
| Thurs Dec 17 | Overview of Exam | ||
|
Fri Dec 18 |
Unit Exam |
Gerneral Reading
Prerequisite: Chapters 7, 8 and section 6.6 of Lodish et al, 6th Ed. Additional reading from recent reviews will be assigned by each lecturer.
Flex-Time
Primary research papers will be presented and discussed. Each student will select a current paper on gene expression (instructors will provide examples). Selected papers will be submitted for Unit leader approval by Friday, December 4, 2009. The Unit Leaders will give sample presentations, and students' initial flex-time presentations on December 8 and 10, 2009 will be in small groups (4-5 students) to maximize questions and input. Within each group, an instructor, postdoc TA or senior student will critique each presentation. Students will present to the entire class on December 11, 14, and 15, 2009. A secondary focus of Flex-times will be discussion of topics or techniques relevant to gene expression arising from lectures that day.
Grading
35% of the Unit grade will derive from in-Unit research paper presentation, and 65% will derive from the Unit exam (closed-book, in-class).
| Date | Lectures | Flex | Instructor |
|---|---|---|---|
|
Tues Jan 5 |
Cell:Extracellular Matrix Interactions | Literature databases |
Bradshaw
(bradshad) |
|
Thurs Jan 7 |
Cell Motility |
|
Bradshaw |
|
Fri Jan 8 |
Cytoskeletal Dynamics | Paper discussion |
Krug
(krugel) |
|
Mon Jan 11 |
Molecular Motors
|
Krug |
|
|
Tues Jan 12 |
Regulation of the Eukaryotic Cell cycle Tumor Suppressor Genes |
Paper discussion |
Wright (wrightcf) |
|
Thurs Jan 14 |
Oncogenes Proto-oncogenes |
Wright Spyropoulos (spyropdd) |
|
|
Fri Jan 15 |
Sorting and Secretion | Paper discussion |
Hunter (huntera) |
|
Mon Jan 18 |
MLK Day - no classes |
|
|
|
Tues Jan 19 |
Integrating Cells into Tissues |
Gourdie (gourdier) |
|
|
Thurs Jan 21 |
Cell Differentiation |
Wooten-Blanks |
|
| Fri Jan 22 | Panel Discussions of Current Literature | Faculty and Class | |
|
Mon Jan 25 |
Panel Discussions of Current Literature |
Faculty and Class |
|
| Tues Jan 26 | Unit Exam |
General Reading
Chap 13, 14, 17-20, 22 and 25, Molecular Cell Biology, 6 th ed., Lodish
Specific Reading
Papers will be posted on WebCT before the relevant lecture.
Dr. Debra Hazen-Martin
Walton Research Building 8th floor complex,
792-2906
hazenmad@@musc.edu
| Date | Lectures | Flex | Instructor |
|---|---|---|---|
|
Thurs Jan 28 |
1.
Introduction
2. Causes, mechanisms, morphology of cell and tissue injury |
Multihead scopes with pathologists. In-Unit assign #1. |
Hazen-Martin (l)*
(hazenmad) |
|
Fri Jan 29 |
1. Cellular adaptations,
cell death, and necrosis
2. Introduction to inflammation and repair |
Tissue injury - a discussion of time-line of events. Assign #1 due. |
Hazen-Martin (l/f)* |
|
Mon Feb 1 |
1.
Components of immune system I
2. Components of immune system II |
Chose
techniques rotation.
In-Unit assign #2. |
London (l/f)
(londonl) |
|
Tues Feb 2 |
1. Immune system III
|
POPS** |
London (l/f) |
|
Thurs Feb 4 |
1. Inflammation in acute cellular injury
2. Immunopathology - 2 examples of inflammation in disease |
No flex; all lecture |
Hazen-Maritn
(l)
S. Self (l) (selfs) |
|
Fri Feb 5 |
No lecture/all flex |
Paper discussion #1 |
Schnellman
(f)
(schnell) |
|
Mon Feb 8 |
No lecture/all flex |
Techniques rotation; in-Unit assign #3 |
|
|
Tues Feb 9 |
1. Cellular senescence
2. Aging |
Techniques follow up - discuss choice of papers with group |
Zhou (l)
(zhoud) Hazen-Martin (f) |
|
Thurs Feb 11 |
1. Apoptosis - historical overview
2. Apoptosis - Causes, mechanisms, and detection |
Promote?/Prevent?
Paper discussion #2 |
Cunningham
(l)
(cunninll) Brown (f) (broweri) Wei (f) (weil) |
|
Fri Feb 12 |
1. Benign and malignant neoplasms
2. Biology of tumor growth |
Work on group presentations. |
Metcalf
(l)
(metcalfj) |
| Mon Feb 15 | Stuent Techniques Presentations | ||
|
Tues Feb 16 |
Unit Exam |
* (l)=lecture, (f)=flex
** a group problem-solving workshop
General reading
Robbins Basic Pathology, 7th edition (on reserve); the following chapters will supplement lecture notes:
| Chapter 1: |
Cellular Injury and response
Aging Apoptosis |
| Chapter 2: | Inflammation |
| Chapter 5: | Diseases of Immunity |
| Chapter 6: | Neoplasia |
If you prefer a more comprehensive version of this text try Robbins Pathologic Basis of Disease which is available on line through MD Consult. Additional articles and/or reviews may be provided in class.
Kuby's Immunology, 6th edition (2006, by Janis Kuby, et.al.) Chapters 1-10 contain basic information that supplements lecture notes.
Specific Reading
Will be posted on WebCT before the relevant lecture and/or assignment.
| Date | Lectures | Flex | Instructor (email) |
|---|---|---|---|
|
Thurs Feb 18 |
1.
Introduction to the Unit
2. Mechanisms of Neurotransmission |
Halushka
(halushpv) Ramamoorthy (rama) |
|
|
Fri Feb 19 |
The Heart and Arterial Pressure Control Mechanisms | Halushka | |
|
Mon Feb 22 |
Autonomic Nervous System Control of the CV System | In Unit Assignment |
Webb
(webbj) |
|
Tues Feb 23 |
Molecular Basis of Atherosclerosis
|
|
Hammad
(hammadsm) |
|
Thurs Feb 25 |
Molecular Mechanism for Aspirin-mediated Cardiovascular Prophylaxis | Halushka | |
|
Fri Feb 26 |
Molecular Basis of Electrical Mechanical Coupling | In Unit Assignment | Menick (menickd) |
|
Mon Mar 1 |
Renal Physiology |
Bell
(bellpd) |
|
|
Tues Mar 2 |
Proteomic Tools for Analysis of Renal Disease | In Unit Assignment | Janech (janechmg) |
|
Wed Mar 3 |
Molecular Mechanisms of Innate Immunity | Cook (cookja) | |
| Thurs Mar 4 | No Class | ||
|
Fri Mar 4 |
Unit Exam |

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