CGS 701/702 Unit Syllabi

Quicklist

  1. Next Unit
  2. Previous Unit
  3. Top
Chemistry of Life Processes

Dr. Craig Beeson
QF 309C, 876-5091
beesonc@musc.edu

Date Date Flex Instructor

Wed Aug 22

 1. Molecular Structure

Tinker Toys

 Beeson

Thu Aug 23

1. Chemical Reactivity Assignment #1 Handout

Structure & Reactivity Questions

 Beeson

Fri Aug 24

1. Solvation and Electrostatics

 Beeson

Mon Aug 27

 1. Biological thermodynamics & kinetics
2. Overview of bioenergetics & redox

 

Beeson

Tue Aug 28

 1.Lipids, bilayers & membranes
2.Transporters & channels

Assignment 1 Due

Beeson

Wed Aug 29

1. Mechanisms in Glycolysis
2. Stuctural Aspects of Regulation Assignment #2 Handout

 

 Beeson

Thu Aug 30

 1. Electron transport chain
2. Chemiosmotic energy transduction & Oxidative Phosphorylation		 Lemasters
Fri Aug 31 1. Beta oxidation & citric acid cycle
2. Mitochondrial physiology		 Assignment 2 Due Lemasters
Mon Sep 3 NO CLASS (Labor Day)    
Tue Sep 4 1. Regulation of catabolism versus anabolism
2. Signaling in regulation of metabolism		   Beeson
Wed Sep 5 1. Probing metabolism in vitro & in vivo Nicholls Paper Beeson
Thu Sep 6 1. Metabolic Dysfunction in Disease Review Chan

Fri Sep 7

 UNIT EXAM  

 

Faculty

Craig Beeson, Ph.D., Drug Discovery and Biomedical Sciences
Sherine Chan, Ph.D., Drug Discovery and Biomedical Sciences
John J. lemasters, MD, Ph.D., Drug Discovery and Biomedical Sciences, Biochemistry and Molecular Biology

General Reading

Lehninger (4th ed) Stryer (7th ed)
Intro to Metabolism
14
14
Bioenergetics
13
Lipids, membranes
10
12
Ion channels
11
13
Glycolysis
14, 15
16
TCA
16
17
Oxidative-Phosph
19
18
Fatty Acid Oxidation
17
22
Pentose Phosphate
15
20
Pathway (HMP-shunt)
Gluconeogenesis
14-15
16
Glycogen Synthesis
15
21
Glycogen Catabolism
15
21
Fatty Acid Synthesis
17
22

Useful Websites:

http://www.bmb.leeds.ac.uk/illingworth/oxphos/
http://www.esf.edu/efb/course/EFB325/default.htm
http://www.aw-bc.com/mathews/
http://www.rpi.edu/dept/bcbp/molbiochem/MBWeb/mb1/MB1index.html

  1. Next Unit
  2. Previous Unit
  3. Top
Macromolecules: Proteins

Dr. Scott Eblen
BSB 313E; 792-1444
eblen@musc.edu

Date Date Flex Instructor

Mon Sept 10

Protein Folding and Stability

 Chan & Dill Paper Beeson/Isaacs

Tues Sept 11

 Protein Modifications

Paper discussion

 Eblen

Wed Sept 12

 Protein-Protein Interactions

Paper discussion

 Hsu

Mon Sept 17

Protein Purification

Flex activity

Hsu

Tues Sept 18

Enzyme Kinetics

Kinetics questions Beeson

Wed Sept 19

 Enzymes and Catalysis Paper discussion Krupenko

Mon Sept 24

 Principles of X-ray Crystallography Flex activity

Davies

Tues Sept 25

 Protein Purification

Flex activity

 Ball

Wed Sept 26

 Protein Characterization/Proteomics Paper discussion Schwacke

Fri Sept 28

 Unit Exam

 

  

Faculty

Craig Beeson, Ph.D., Drug Discovery and Biomedical Sciences
Jennifer Isaacs, Ph.D., Cell and Molecular Pharmacology
Scott Eblen, Ph.D., Cell and Molecular Pharmacology
Yi-Te Hsu, Ph.D., Cell and Molecular Pharmacology
Chris Davies, Ph.D., Biochemistry and Molecular Biology
Lauren Ball, Ph.D., Cell and Molecular Pharmacology
Sergey Krupenko, Ph.D., Biochemistry and Molecular Biology
John Schwacke, Ph.D., Biochemistry and Molecular Biology

General reading Prerequisite readings for this Unit are Chapters 2, 3, 8, 9, 10, 23.1, 23.2, 30.4 and 30.5
in Stryer 7th Ed.

All assignments are due by 10:00am on the assigned date: bring completed assignments to class. Read Assigned papers before class and be prepared to discuss them.

  1. Next Unit
  2. Previous Unit
  3. Top
Receptors & Signaling

Dr. Steven A. Rosenzweig
BSB 313G; 792-5841
rosenzsa@@musc.edu

Date Date Flex Instructor

Mon Oct 8

 Overview of receptors & signaling I

Receptor tyrosine kinases

 Rosenzweig

Tues Oct 9

 G protein coupled receptors

Paper discussion (1)

 Blumer

Wed Oct 10

 G proteins and their regulatory proteins

Paper discussion (2)

 Blumer

Mon Oct 15

 Photoreceptors

Paper discussion (3)

 Koutalos

Tues Oct 16

Protein: protein interactions in signal transduction

Methods for identifying/studying protein interactions

 Ball

Wed Oct 17

 Protein kinases: MAP kinases

Paper discussion (5)

 Eblen

Mon Oct 22

 Signaling to apoptosis Methods exercise Voelkel-Johnson
Tues Oct 23 Cell Signaling in response to hypoxia Paper discussion (4) Isaacs
Wed Oct 24 The Pl3 kinase signaling pathway in disease Paper discussion (7) Muise-Helmericks

Fri Oct 26

 Unit Exam

 

  

Faculty

Steven Rosenzweig, Ph.D., Cell and Molecular Pharmacology
Joe Blumer, Ph.D., Cell and Molecular Pharmacology
Yiannis Koutalos, Ph.D., Ophthalmology
Lauren Ball, Ph.D., Cell and Molecular Pharmacology
Scott Eblen, Ph.D., Cell and Molecular Pharmacology
Christina Voelkel-Johnson, Ph.D., Cell and Molecular Pharmacology
Jennifer Isaacs, Ph.D., Cell and Molecular Pharmacology
Robin Muise-Helmericks, Ph.D., Regenerative Medicine and Cell Biology

General reading

Prerequisite: Chapters 15, 17 & 20 of Molecular Biology of the Cell, 5th Ed, Alberts et al.

Specific Reading

Papers will be posted on Moodlerooms as required



  1. Next Unit
  2. Previous Unit
  3. Top
Macromolecules: Nucleic Acids

Dr. Ashley Cowart
STB 421; 789-6796
cowartl@musc.edu

Date Date Flex Instructor

Mon Oct 29

Introduction to Unit
1. History
2. Nucleic Acid Structure

 Hot Topic: Riboswitches Hennig

Tues Oct 30

 1. Prokaryotic DNA Biosynthesis and Packaging
2. Eukaryotic DNA Biosynthesis and Packaging		   Mohanty

Wed Oct 31

 1.DNA Damage, Damage Checkpoints, and Repair
2. Recombination

 

Mohanty

Mon Nov 5

 1. How the Genetic Code was Deciphered
2. Prokaryotic Transcription and its Regulation		   Cowart

Tues Nov 6

 Election Day: No Classes    

Wed Nov 7

1. Prokaryotic Translation
2. tRNA Synthetases, Ribosome Structure

   Heise
Davies

Thurs Nov 8

 1, 2. Catalytic RNA and its applications

Hot Topic: tmRNA

 Hennig

Mon Nov 12

 1, 2. Techniques in Nucleic Acid Research

 

 Kurtz

Tues Nov 13

 1. Genetics and Evolution

 

Kurtz
Wed Nov 14 Student Presentations  

Fri Nov 16

 Unit Exam  

Faculty

Mirko Hennig, Ph.D., Biochemistry and Molecular Biology
Bidyut Mohanty, Ph.D., Biochemistry and Molecular Biology
Ashley Cowart, Ph.D., Biochemistry and Molecular Biology
Tilman Heise, Ph.D., Biochemistry and Molecular Biology
Chris Davies, Ph.D., Biochemistry and Molecular Biology
David Kurtz, Ph.D., Cell and Molecular Pharmacology

General reading

Prerequisite: Chapters 4-7 of Molecular Biology of the Cell, 5th Ed, Alberts et al. Also useful are Chapters 4, 5, 28, 29 & 30 in Stryer, 6th ed.

 

  1. Next Unit
  2. Previous Unit
  3. Top
Regulation of Gene Expression

Dr. Donald Menick
Gazes/Strom Thurmond 203; 876-5045
menickd@@musc.edu

Date Date Flex Instructor

Mon Nov 26

1. Eukaryotic Transcription/Regulation of Gene Expression I
2. Eukaryotic Transcription/Regulation of Gene Expression II

Discussion of Student presentations

 Kurtz

Tues Nov 27

 3. Integrating Transcriptional Regulation Signaling Events
4. Epigenetic Regulation of Gene Expression 		  Kurtz

Wed Nov 28

5. HDAC's and HAT's Role in Gene Expression I
6. HDAC's and HAT's Role in Gene Expression II

Menick

Mon Dec 3

7. Micro RNAs I
8. Micro RNAs II

TBA Menick

Tues Dec 4

9. Regulation of mRNA Processing and Localization I
10. Regulation of mRNA Processing and Localization II

Practice talks Heise

Wed Dec 5

11. Regulation of mRNA Stability and Translation
12. Regulation of Translation and Degradation

Practice talks

Heise

Mon Dec 10

Student presentations of research papers

 

  

Tues Dec 11

 Student presentations of research papers
Wed Dec 12 Student presentations of research papers Overview of Exam
Fri Dec 14 Unit Exam

Faculty

David Kurtz, Ph.D., Cell and Molecular Pharmacology
Donald Menick, Ph.D., Medicine
Tilman Heise Ph.D., Biochemistry & Molecular Biology

Gerneral Reading

Prerequisite: Chapters 7, 8 and section 6.6 of Lodish et al, 6th Ed. Additional reading from recent reviews will be assigned by each lecturer.

Flex-Time

Primary research papers will be presented and discussed. Each student will select a current paper on gene expression (instructors will provide examples). Selected papers will be submitted for Unit leader approval by Friday, December 2, 2012. The Unit leader will give guidelines for the presentation, and grading criteria during the first Flex-time. Students will have a practice session with a TA on December 4 or 5, 2012. This will be done with 3 students and the TA will critique each presentation. In these practice sessions students will have the opportunity to ask questions and get very good input on their presenation. Students will give their formal presentation to the entire class on December 10, 11, and 12, 2012. A secondary focus of Flex-times will be discussion of topics or techniques relevant to gene expression.

Grading

25% of the Unit grade will derive from in-Unit research paper presentation, and 75% will derive from the Unit exam (closed-book, in-class).

  1. Next Unit
  2. Previous Unit
  3. Top
Cellular Functions

Dr. Robert Gemmill
Hcc 712B; 792-4643
gemmill@@musc.edu

Date Date Flex Instructor

Mon Jan 7

 Overview Lectures Literature databases All Faculty
Gemmill

Tues Jan 8

 Integration of Growth Signals

 

Gemmill

Wed Jan 9

 Cell: Extracellular Matrix Interactions   Bradshaw

Thur Jan 10

Cell: Extracellular Matrix Interactions

  

Bradshaw

Mon Jan 14

Cell Motility

 

Nasarre

Tues Jan 15

Cell Motility   Nasarre

Wed Jan 16

Oncogenes/tumor suppressors   Findlay
Mon Jan 21 MLK Day - no class    

Tues Jan 22

Oncogenes/tumor suppressors

 

Findlay

Wed Jan 23

 Panel Discussions of Current Literature Faculty and class

Fri Jan 25

Unit Exam

 

General Reading
Chapters 13, 14, 17-20, 22 and 25 Molecular Cell Biology, 6th edition, Lodish

Specific Reading

Papers will be posted on Moodle before the relevant lecture

  1. Next Unit
  2. Previous Unit
  3. Top
Cell Injury and Response

Dr. Julie Woolworth
Children's Hospital, EH 222A, 792-1181
woolworj@@musc.edu

Date Date Flex Instructor

Mon Jan 28

 1. Introduction
2. Causes, mechanisms, morphology of cell and tissue injury

Multihead scopes with pathologists. In-Unit assignment #1.

Hazen-Martin

Tues Jan 29

 1. Cellular adaptations, cell death, and necrosis
2. Inflammation and repair

Discuss and submit assignment #1 in class

 Hazen-Martin

Wed Jan 30

 1. Inflammation/acute cell injury
2. Chemical mediators inflammation
3. Chronic inflammation/resolution		 Turn in final version assignment @1 Hazen-Martin

Mon Feb 4

1. Immune System I

In-class assignment #2

Kasman

Tues Feb 5

 1. Immune System II

In-class activity #3;
receive assignment #4

Hazen-Martin (l)
Self (l)

Wed Feb 6

 Techniques Rotation Day

Techniques Rotation

  

Mon Feb 11

Prepare paper discussion with group members

Dr. Schnellmann article discussion #4

Tues Feb 12

 1. Immunopathology organ transplant rejection

Group 1 and 2 technique presentations

  

Wed Feb 13

 Review Group 3 and 4 technique presentations  

Fri Feb 15

 Unit Exam

 

 

Faculty

Debra Hazen-Martin, Ph.D., Pathology & Laboratory Medicine
Laura Kasman, Ph.D., Microbiology & Immunology
Richard Schnellmann, Ph.D., Drug Discovery and Biomedical Sciences
John Metcalf, M.D., Pathology & Laboratory Medicine
Erika Brown, Ph.D., Pathology & Laboratory Medicine
Julie Woolworth, Ph.D., Pathology & Laboratory Medicine

General reading

Robbins Basic Pathology, 7th edition (on reserve); the following chapters will supplement lecture notes:

Chapter 1: Cellular Injury and response
Aging
Apoptosis
Chapter 2: Inflammation
Chapter 5: Diseases of Immunity
Chapter 6: Neoplasia

If you prefer a more comprehensive version of this text try Robbins Pathologic Basis of Disease which is available on line through MD Consult. Additional articles and/or reviews may be provided in class.

Kuby's Immunology, 6th edition (Kuby et.al. 2006) Chapters 1-10 contain basic information that supplements lecture notes.

Specific Reading

Will be posted on Moodlerooms before the relevant lecture and/or assignment.

  1. Previous Unit
  2. Top
Systems Biology

Dr. Perry Halushka
BE 101; 876-2402
Lectures: BSB 435
halushpv@@musc.edu

Date Date Flex Instructor (email)

Mon Feb 18

 1. Introduction to the Unit
2. The Heart and Arterial Pressure Control Mechanisms		 Halushka

Tues Feb 19

 1. Cardiovascular Diseases/Hypertension Lackland

Wed Feb 20

 1. Mechanisms of Atheroscierosis   Hammad

Mon Feb 25

1. Renal Physiology

Bell

Tues Feb 26

 1. Renal Disease  

Wed Feb 27

 1. Pulmonary Physiology   Koutalos

Mon Mar 4

1. Pulmonary
2. Pathophysiology/COPD/Asthma

Atkinson

Tues Mar 5

 1. Endocrinology/Pancreas/Thyroid glands   Ondo

Wed Mar 6

 1. Endocrine Disorders: Diabetes Mellitus Hermayer

Fri Mar 8

 Unit Exam  

Faculty

Perry Halushka, Ph.D., M.D., Medicine/Pharmacology
Samar Hammad, Ph.D., Medicine
Darwin Bell, Ph.D., Medicine
Dan Lackland, DRPH, Neuroscience
Ioannis Koutalos, Ph.D., Ophthalmology
Carl Atkinson, Ph.D., Microbiology and Immunology
Jerry Ondo, Ph.D., Neuroscience
Kathy Hermayer, M.D., Medicine

Previous | Next