Quicklist
Drs. Yi-Te Hsu
CRI 311; 792-4367
Craig Beeson
BSB 518; 792-0849
| Date | Date | Flex | Instructor |
|---|---|---|---|
|
Thurs Aug 21 |
Molecular Structure |
Beeson | |
|
Fri Aug 22 |
Chemical Reactivity |
|
Beeson |
|
Mon Aug 25 |
Solvation and Electrostatics |
|
Dix |
|
Tues Aug 26 |
Transition State Theory |
Dix/Beeson |
|
|
Thurs Aug 28 |
Principles of X-ray Crystallography | Davies | |
|
Fri Aug 29 |
Protein Modification | Eblen | |
|
Tues Sept 2 |
Protein Folding and Stability |
TBA |
|
|
Thurs Sept 4 |
Protein-Protein Interactions |
|
Hsu |
|
Fri Sept 5 |
Enzymes and Catalysis | Krupenko | |
|
Mon Sept 8 |
Enzyme Kinetics |
|
Beeson |
| Tues Sept 9 | Protein Purification | Hennig | |
| Thurs Sept 11 | Protein Characterization/Proteomics | Ball | |
| Fri Sept 12 | Proteomics/Informatics | Schwacke | |
| Mon Sept 15 | Global Overview | Beeson/Hsu | |
| Tues Sept 16 | Unit Exam |
General reading Prerequisite reading for this Unit is Stryer's Biochemistry (6th Ed, Chapters 3, 4 and 8) or Lehninger's Principles of Biochemistry (5th Ed., Chapter 3-6).
| Date | Date | Flex | Instructor |
|---|---|---|---|
|
Thurs Sept 18 |
Introduction to Unit 1. History, DNA structure 2. A, B & Z forms, W&C, base pairing |
Kurtz Schweinfest |
|
|
Fri Sept 19 |
1. Genetic code 2. Superhelicity + topoisomerases |
Schweinfest Hennig |
|
|
Mon Sept 22 |
1.
DNA replication-DNA polymerases 2. DNA replication (continued) |
|
Brown |
|
Tues Sept 23 |
1. Recombination 2. DNA repair |
Brown | |
|
Thurs Sept 25 |
1. tRNA synthetases, translation 2. Structure of the ribosome - decoding |
Davies | |
|
Fri Sept 26 |
1. Catalytic RNA & RNA processing 2. RNA interference |
Davies | |
|
Mon Sept 29 |
1. Transcription in prokaryotic genes 2. Mechanisms of transcriptional regulation |
|
Davies |
|
Tues Sept 30 |
Techniques in Nucleic acids research |
|
Kurtz |
|
Thurs Oct 2 |
Pharmacogenetics |
|
Kurtz |
| Fri Oct 3 | Genomics/epigenetics | Wolff | |
| Mon Oct 6 | Student presentations | Kurtz | |
| Tues Oct 7 | Student presentations | Kurtz | |
| Thurs Oct 8 | Student presentations | Kurtz | |
|
Fri Oct 9 |
Unit Exam | Kurtz |
General reading
Prerequisite: Chapters 4-7 of Molecular Biology of the Cell, 5th Ed, Alberts et al. Also useful are Chapters 4, 5, 28, 29 & 30 in Stryer, 6th ed.
| Date | Date | Flex | Instructor |
|---|---|---|---|
|
Mon Oct 13 |
1.
Biological thermodynamics & kinetics
2. Overview of bioenergetics & Redox |
|
Beeson |
|
Tues Oct 14 |
1. Lipids, bilayers &
membranes
2. Membrane biophysics |
|
Beeson |
|
Thurs Oct 16 |
1.
Transporters & channels: classes, function
2. Transporters & channels: techniques |
|
Covington |
|
Fri Oct 17 |
1. Overview of catabolism, anabolism 2. Signaling in regulation of metabolism |
|
Beeson |
|
Mon Oct 20 |
1. Mechanisms in Glycolysis 2. Gluconeogenesis |
|
Davies |
|
Tue Oct 21 |
1. Structural Aspects of Regulation |
|
Davies |
|
Thu Oct 23 |
1. Citric Acid Cycle 2. Beta oxidation |
|
Lemasters |
|
Fri Oct 24 |
1. Electron transport chain 2. Biophysics of mitochondrial membranes |
|
Lemasters |
|
Mon Oct 27 |
1. Chemiosmotic energy transduction 2. Oxidative Phosphorylation |
|
Lemasters |
| Tue Oct 28 | 1. Glycogen metabolism 2. Fatty acid biosynthesis |
Beeson | |
| Thu Oct 30 | Integrative metabolism and metabolomics | Beeson | |
|
Fri Oct 31 |
Final Exam |
|
Background Reading Material
| Biochemistry | Lehninger (5th Ed) | Stryer (6th Ed.) |
|---|---|---|
| Intro to Metabolism | 14 | 15 |
| Bioenergetics | 13 | |
| Lipids, membranes | 10 | 12 |
| Ion channels | 11 | 13 |
| Glycolysis | 14, 15 | 16 |
| TCA | 16 | 17 |
| Oxidative-Phosph | 19 | 18 |
| Fatty Acid Oxidation | 17 | 22 |
| Pentose Phosphate Pathway (HMP-shunt) |
15 | 20 |
| Gluconeogenesis | 14-15 | 16 |
| Glycogen Synthesis | 15 |
21 |
| Glycogen Catabolism | 15 |
21 |
| Fatty Acid Synthesis | 21 | 22 |
Useful Websites:
http://www.bmb.leeds.ac.uk/illingworth/oxphos/
http://www.esf.edu/efb/course/EFB325/default.htm
http://www.rpi.edu/dept/bcbp/molbiochem/MBWeb/mb1/MB1index.html
| Date | Date | Flex | Instructor |
|---|---|---|---|
|
Mon Nov 3 |
1. Overview of receptors & signaling I |
Methods of Studying Ligand:Receptor Interactions |
Rosenzweig (rosenzsa) |
|
Tues Nov 4 |
1. G protein coupled receptors |
Paper discussion (1) |
Blumer (blumerjb) |
|
Thur Nov 6 |
G proteins and their regulatroy proteins |
Paper discussion (2) |
Blumer |
|
Mon Nov 10 |
Photoreceptors |
Paper discussion (3) |
Koutaios (koutalo) |
|
Tues Nov 12 |
Receptor tyrosine kinases |
Paper discussion (4) |
Rosenzweig |
|
Thur Nov 13 |
Protein: protein interactions in signal transduction |
Paper discussion (5) |
Ball (balle) |
|
Fri Nov 14 |
Receptor tyrosine kinase signaling to cell migration | Paper discussion (6) | Isaacs (isaacsj) |
| Mon Nov 17 | Protein kinases: MAP kinases | Paper discussion (7) | Eblen (eblen) |
| Tues Nov 18 | TGF- b Receptors and the Smads | Paper discussion (8) | Eblen |
| Thur Nov 20 | Signaling to apoptosis | Methods exercise | Voelkel-Johnson (johnsov) |
| Fri Nov 21 | Cell signaling in disease: cancer | Paper discussion (9) | Rosenzweig |
| Mon Nov 24 | Cell signaling in disease: Animal models of Cancer | Paper discussion (10) | Neumann (neumannc) |
|
Tues Nov 25 |
Unit Exam |
|
General reading
Prerequisite: Chapters 15, 17 & 23 of Molecular Biology of the Cell, 5th Ed, Alberts et al.
Specific Reading
Papers will be posted on WebCT as required
Dr. Donald Menick
Gazes/Strom Thurmond 203; 876-5045
menickd@@musc.edu
| Date | Date | Flex | Instructor |
|---|---|---|---|
|
Mon Dec 1 |
1. Eukaryotic Transcription/Regulation of Gene Expression I |
Discussion of student presentations |
Kyu-Ho Lee (leeh) |
|
Tues Dec 2 |
3: Integrating
Transcriptional Regulation Signaling Events
4: Epigenetic Regulation of Gene Expression |
Kyu-Ho Lee | |
|
Thurs Dec 4 |
5. HDAC's and HAT's Role in Gene Expression |
Menick (menickd) | |
|
Fri Dec 5 |
7. RNA Interference I |
Menick | |
|
Mon Dec 8 |
9. Regulation of mRNA Processing and Localization I |
McDermott (mcdermp) | |
|
Tues Dec 9 |
11: Regulation of mRNA Stability and Translation |
Practice talks |
McDermott |
|
Thurs Dec 11 |
13. Viral Models for Molecular Biology I |
Practice talks |
Wright (wrightcf) |
|
Fri Dec 12 |
Student presentations of research papers | ||
| Mon Dec 15 | Student presentations of research papers | ||
| Tues Dec 16 | Student presenations of research papers | ||
| Thurs Dec 18 | Overview of Exam | ||
|
Fri Dec 19 |
Unit Exam |
Gerneral Reading
Prerequisite: Chapters 7, 8 and section 6.6 of Lodish et al, 6th Ed. Additional reading from recent reviews will be assigned by each lecturer.
Flex-Time
Primary research papers will be presented and discussed. Each student will select a current paper on gene expression (instructors will provide examples). Selected papers will be submitted for Unit leader approval by Friday, December 5, 2008. The Unit Leaders will give sample presentations, and students' initial flex-time presentations on December 9 and 11, 2008 will be in small groups (4-5 students) to maximize questions and input. Within each group, an instructor, postdoc TA or senior student will critique each presentation. Students will present to the entire class on December 12, 15, and 16, 2008. A secondary focus of Flex-times will be discussion of topics or techniques relevant to gene expression arising from lectures that day.
Grading
35% of the Unit grade will derive from in-Unit research paper presentation, and 65% will derive from the Unit exam (closed-book, in-class).
| Date | Date | Flex | Instructor |
|---|---|---|---|
|
Thurs Jan 8 |
Cell:Extracellular Matrix Interactions |
Bradshaw
(bradshad) |
|
|
Fri Jan 9 |
Cell Motility |
Paper discussion |
Bradshaw |
|
Mon Jan 12 |
Cytoskeletal Dynamics |
Krug
(krugel) |
|
|
Tues Jan 13 |
Molecular Motors
|
Krug |
|
|
Thurs Jan 15 |
Secretion and Vesicular Trafficking |
Paper discussion |
Krug |
|
Fri Jan 16 |
The Eukaryotic Cell Cycle |
Kurtz
(kurtzdt) |
|
|
Mon Jan 19 |
Oncogenes and cancer | Kurtz | |
|
Tues Jan 20 |
Tumor suppressor genes |
Paper discussion |
Kurtz |
|
Thurs Jan 22 |
Integrating Cells Into Tissues |
Gourdie
(gourdier) |
|
|
Fri Jan 23 |
Panel Discussions of Current Literature |
Faculty and Class |
|
| Tues Jan 27 | Panel Discussions of Current Literature | Faculty and Class | |
|
Thurs Jan 29 |
Unit Exam |
|
General Reading
Chap 6, 16, 17, 19, 20, 21 and 23, Molecular Cell Biology, 5th ed., Lodish
Specific Reading
Papers will be posted on WebCT before the relevant lecture.
Dr. Debra Hazen-Martin
Walton Research Building 8th floor complex,
792-2906
hazenmad@@musc.edu
| Date | Date | Flex | Instructor |
|---|---|---|---|
|
Fri Jan 30 |
1.
Introduction
2. Causes, mechanisms, morphology of cell and tissue injury |
Multihead scopes with pathologists. In-Unit assign #1. |
Hazen-Martin (l)*
(hazenmad) |
|
Mon Feb 2 |
1. Cellular adaptations,
cell death, and necrosis
2. Introduction to inflammation and repair |
Tissue injury - a discussion of time-line of events. Assign #1 due. |
Hazen-Martin (l/f)* |
|
Tues Feb 3 |
1.
Components of immune system I
2. Components of immune system II |
Chose
techniques rotation.
In-Unit assign #2. |
L. London (l/f)
(londonl) |
|
Thurs Feb 5 |
1. Immune system III
|
POPS** |
L. London (l/f) |
|
Fri Feb 6 |
1. Inflammation in acute cellular injury
2. Immunopathology - 2 examples of inflammation in disease |
No flex; all lecture |
Hazen-Maritn
(l)
S. Self (l) (selfs) |
|
Mon Feb 9 |
No lecture/all flex |
Paper discussion #1 |
Schnellman
(f)
(schnell) |
|
Tues Feb 10 |
No lecture/all flex |
Techniques rotation; in-Unit assign #3 |
|
|
Thurs Feb 12 |
1. Cellular senescence
2. Aging |
Techniques follow up - discuss choice of papers with group |
Zhou (l)
(zhoud) Hazen-Martin (f) |
|
Fri Feb 13 |
1. Apoptosis - historical overview
2. Apoptosis - Causes, mechanisms, and detection |
Promote?/Prevent?
Paper discussion #2 |
Cunningham
(l)
(cunninll) Brown (f) (broweri) Wei (f) (weil) |
|
Mon Feb 16 |
1. Benign and malignant neoplasms
2. Biology of tumor growth |
Work on group presentations. |
Metcalf
(l)
(metcalfj) |
| Tues Feb 17 | Stuent Techniques Presentations | ||
| Thurs Feb 19 | |||
|
Fri Feb 20 |
Unit Exam |
* (l)=lecture, (f)=flex
** a group problem-solving workshop
General reading
Robbins Basic Pathology, 7th edition (on reserve); the following chapters will supplement lecture notes:
| Chapter 1: |
Cellular Injury and response
Aging Apoptosis |
| Chapter 2: | Inflammation |
| Chapter 5: | Diseases of Immunity |
| Chapter 6: | Neoplasia |
If you prefer a more comprehensive version of this text try Robbins Pathologic Basis of Disease which is available on line through MD Consult. Additional articles and/or reviews may be provided in class.
Kuby's Immunology, 6th edition (2006, by Janis Kuby, et.al.) Chapters 1-10 contain basic information that supplements lecture notes.
Specific Reading
Will be posted on WebCT before the relevant lecture and/or assignment.
Dr. Perry Halushka
BSB 102B1; 792-3012
halushpv@@musc.edu
Dr. James Cook
SEI 611; 792-2978
cookja@@musc.edu
| Date | Date | Flex | Instructor (email) |
|---|---|---|---|
|
Mon Feb 23 |
1.
Introduction to the Unit
2. Molecular Mechanism for Aspirin Mediated Cardiovascular Prophylaxis |
Halushka
(halushpv) |
|
|
Tues Feb 24 |
1. Mechanisms of Neurotransmission |
Ramamoorthy
(rama) |
|
|
Thurs Feb 26 |
1. Autonomic Nervous System Control of the CV System |
Webb
(webbj) |
|
|
Fri Feb 27 |
1. Molecular Basis of Electrical Mechanical Coupling
|
|
Menick
(menickd) |
|
Mon Mar 2 |
1. Molecular/Genetic Basis of Congenital Heart Disease |
McQuinn
(mcquinnt) |
|
|
Tues Mar 3 |
1. Molecular Basis of Atherosclerosis |
Hammad
(hammadsm) |
|
|
Thurs Mar 5 |
1. Molecular Basis of Neurodegenerative Diseases |
Granholm
(granholm) |
|
|
Fri Mar 6 |
1. Renal Physiology |
Bell
(bellpd) |
|
|
Mon Mar 9 |
1. Proteomic Tools for Analysis of Renal Disease |
Arthur
(arthurj) |
|
|
Tues Mar 10 |
1. Microbial Basis of Infectious Diseases |
John
(johnjf) |
|
| Thurs Mar 12 | 1. Molecular Mechanisms of Innate Immunity | Cook (cookja) | |
|
Fri Mar 13 |
Unit Exam |

Top
Previous Unit