Publications

George Cooper IV, M.D. Dhandapani Kuppuswamy, Ph.D.
Paul J. McDermott, Ph.D. Donald R. Menick, Ph.D.
Terrence X. O'Brien, M.D., F.A.C.C. Michael Zile, M.D.

George Cooper IV, M.D.

Tanaka, R., Barnes, M.A., Cooper, G., and Zile, M.R.: Effects of Anisosmotic Stress on Cardiac Muscle Cell Length, Diameter, Area, and Sarcomere Length. Am. J. Physiol., 270: H1414-1422, 1996.

Tagawa, H., Rozich, J.D., Narishige, T., Kuppuswamy, D., Tsutsui, H., McDermott, P.J., Koide, M., and Cooper, G.: Basis for Increased Microtubules in Pressure Hypertrophied Cardiocytes. Circulation, 93: 1230-1243, 1996.

Tagawa, H., Koide, M., Sato, H., and Cooper, G.: Cytoskeletal Role in the Contractile Dysfunction of Cardiocytes from Hypertrophied and Failing Right Ventricular Myocardium. Proc. Assoc. Am. Physicians, 108: 218-229, 1996.

Wada, H., Ivester, C.T., Carabello, B.A., Cooper, G., and McDermott, P.J.: Translation Initiation Factor eIF-4E: A Link Between Cardiac Load and Protein Synthesis. J. Biol. Chem., 271: 8359-8364, 1996.

Menick, D.R., Barnes, K.V., Thacker, U.F., Dawson, M.M., McDermott, D.E., Rozich, J.D., Kent, R.L., and Cooper, G.: The Exchanger and Cardiac Hypertrophy. Ann. NY Acad. Sci., 779: 489-501, 1996.

Wada, H., Zile, M.R., Ivester, C.T., Cooper, G., and McDermott, P.J.: Comparative Effects of Contraction and Angiotensin II on Growth of Adult Feline Cardiocytes in Primary Culture. Am. J. Physiol., 271: H29-37, 1996.

Cooper, G.: Basic Mechanisms of Myocardial Hypertrophy: A Review of Molecular Mechanisms. Annu. Rev. Med., 48: 13-23, 1997.

Menick, D.R., Barnes, K.V., Dawson, M.M., Kent, R.L., and Cooper, G.: Gene Expression of the Na-Ca Exchanger in Cardiac Hypertrophy. J. Cardiac Failure, 2: 569-576, 1996.

Kato, S., Koide, M., Cooper, G., and Zile, M.R.: Effects of Pressure or Volume Overload Hypertrophy on Passive Stiffness in Isolated Adult Cardiac Muscle Cells. Am. J. Physiol., 271: H2575-2583, 1996.

Tagawa, H., Wang, N., Narishige, T., Ingber, D.E., Zile, M.R., and Cooper, G.: Cytoskeletal Mechanics in Pressure Overload Cardiac Hypertrophy. Circ. Res., 80: 281-289, 1997.

Kuppuswamy, D., Kerr, C., Narishige, T., Kasi, V.S., Menick, D.R., and Cooper, G.: Association of Tyrosine Phosphorylated pp60c-Src with the Cytoskeleton of Hypertrophying Myocardium. J. Biol. Chem., 272: 4500-4508, 1997.

Koide, M., Nagatsu, M., Zile, M.R., DeFreyte, G., Tagawa, H., Cooper, G., and Carabello, B.A.: Premorbid Determinants of Left Ventricular Dysfunction in a Novel Model of Gradually Induced Pressure Overload in the Adult Canine. Circulation, 95: 1601-1610, 1997.

Sato, H., Nagai, T., Kuppuswamy, D., Narishige, T., Koide, M., Menick, D.R., and Cooper, G.: Microtubule Stabilization in Pressure Overload Cardiac Hypertrophy. J. Cell. Biol., 139: 963-973, 1997.

Zile, M.R., Richardson, K., Cowles, M.K., Buckley, J.M., Koide, M., Cowles, B.A., Gharpuray, V., and Cooper, G.: Constitutive Properties of Adult Mammalian Cardiac Muscle Cells. Circulation, 98: 567-579, 1998.

Hamawaki, M., Coffman, T.M., Lashus, A., Koide, M., Zile, M.R., Oliverio, M.I., DeFreyte, G., Cooper, G., and Carabello, B.A.: Pressure Overload Hypertrophy Is Unabated in Mice Devoid of AT1A Receptors. Am. J. Physiol., 274: H868-873, 1998.

Tagawa, H., Koide, M., Sato, H., Zile, M.R., Carabello, B.A., and Cooper, G.: Cytoskeletal Role in the Transition from Compensated to Decompensated Hypertrophy During Adult Canine Left Ventricular Pressure Overloading. Circ. Res., 82: 751-761, 1998.

Zile, M.R., Cowles, M.K., Buckley, J.M., Richardson, K., Cowles, B.A., Baicu, C.F., Cooper, G., and Gharpuray, V.: Gel Stretch Method: A New Method to Measure Constitutive Properties of Cardiac Muscle Cells. Am. J. Physiol., 274: H2188-2202, 1998.

Laser, M., Kasi, V.S., Hamawaki, M., Cooper, G., Kerr, C.M., and Kuppuswamy, D.: Differential Activation of p70 and p85 S6 Kinase Isoforms during Cardiac Hypertrophy in the Adult Mammal. J. Biol. Chem., 273: 24610-24619, 1998.

Zile, M.R., Koide, M., Sato, H., Ishiguro, Y., Conrad, C.H., Buckley, J.M., Morgan, J.P., and Cooper, G.: Role of Microtubules in the Contractile Dysfunction of Hypertrophied Myocardium. J. Am. Coll. Cardiol., 33: 250-260, 1999.

Nagai, T., Laser, M., Baicu, C.F., Zile, M.R., Cooper, G., and Kuppuswamy, D.: b3-Integrin-Mediated Focal Adhesion Complex Formation: Adult Cardiocytes Embedded in Three-Dimensional Polymer Matrices. Am. J. Cardiol., 83: 38H-43H, 1999.

Koide, M., Carabello, B.A., Conrad, C.C., Buckley, J.M., DeFreyte, G., Barnes, M., Tomanek, R.J., Wei, C.C., Dell'Italia, L.J., Cooper, G., and Zile, M.R.: Hypertrophic Response to Hemodynamic Overload: Role of Load vs. Renin-Angiotensin System Activation. Am. J. Physiol., 276: H350-358, 1999.

Narishige, T., Blade, K.L., Ishibashi, Y., Nagai, T., Hamawaki, M., Menick, D.R., Kuppuswamy, D., and Cooper, G.: Cardiac Hypertrophic and Developmental Regulation of the b-Tubulin Multigene Family. J. Biol. Chem., 274: 9692-9697, 1999.

Nagatsu, M., Spinale, F.G., Koide, M., Tagawa, H., DeFreitas, G., Cooper, G., and Carabello, B.A.: Bradycardia and the Role of b-Blockade in the Amelioration of Left Ventricular Dysfunction. Circulation, 101: 653-659, 2000.

Laser, M., Willey, C.D., Jiang, W., Cooper, G. 4th, Menick, D.R., Zile, M.R., Kuppuswamy, D. Integrin activation and focal complex formation in cardiac hypertrophy. J Biol Chem. Nov 10; 275 (45): 35624-30 (2000).

 

Papers Submitted or In Preparation

Rackley, M.S., Thompson, J.T., Hamawaki, M., McDermott, P.J., Cooper, G., and O'Brien, T.X.: Early Initiation Factor 2-a Is Upregulated During Cardiac Hypertrophy Induced by Hemodynamic Pressure Overload. Am. J. Physiol., Submitted.

Zile, M.R., Buckley, J.M., Tagawa, H., Richardson, K., Cowles, M.K., Gharpuray, V., Koide, M., and Cooper, G.: Effects of Pressure Overload Hypertrophy on Passive Stiffness and Viscous Damping in Adult Mammalian Cardiac Muscle Cells. Biophys. J., Submitted.

O'Brien, T.X., Menick, D.R., Rackley, M.S., McDermott, P.J. and Cooper, G.: F1-ATP Synthase Activation by Right Ventricular Load and Enhancer Inducibility in Cardiocytes. Am. J. Physiol., Submitted.

Koide, M., Hamawaki, M.. Narishige, T., Sato, H., DeFreyte, G., Cooper, G., and Carabello, B.A.: Microtubule Depolymerization Normalizes Ventricular Contractile Dysfunction in Intact Dogs with Left Ventricular Hypertrophy. J. Clin. Invest., Submitted.

Zile, M.R., Green, G.R., Schuyler, G.T., Aurigemma, G.P., Miller, D.C., and Cooper, G.: Cytoskeletal Changes in Patients with Left Ventricular Pressure Overload Hypertrophy. N. Engl. J. Med., Submitted.

 

Book Chapters

Menick, D.R., Barnes, K.V., Dawson, M.M., Kent, R.L., and Cooper, G.: Regulation of the Na-Ca Exchanger Expression in Cardiac Hypertrophy. In: Heart Failure: New Insights into Mechanisms and Management. Eds.: S. Sasayama, J. Ross, Jr., and D.L. Brutsaert. Churchill Livingstone, Tokyo, Japan, 1996, pp. 69-76.

Laser, M., Nagai, T., Kasi, V.S., Baicu, C.F., Wiley, C.D., Zile, M.R., Cooper, G., and Kuppuswamy, D.: Integrin-Dependent and -Independent Signaling during Pressure Overload Hypertrophy. In: The Hypertrophied Heart. Eds.: Takeda, N., Nagano, M., and Dhalla, K. Kluwer Academic Publishers, Boston, MA, 1999.

 

Reviews

Cooper, G.: What Is the Stimulus to Cardiac Growth? ACCEL, 28: 1997.

Cooper, G.: Basic Mechanisms of Myocardial Hypertrophy: A Review of Molecular Mechanisms. Annu. Rev. Med., 48: 13-23, 1997.

Tsutsui, H., Tagawa, H., Cooper, G., and Takeshita, A.: Role of Microtubules in the Transition from Compensated Cardiac Hypertrophy to Failure. Heart Failure Reviews, In press.

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Dhandapani Kuppuswamy, Ph.D.

Tagawa, H., Roszich, J. D., Tsutsui, H., Narishige, T., Kuppuswamy, D., Sato, H., McDermott, P. J., Koide, M. and Cooper, IV, G. Basis for increased microtubules in pressure hypertrophied cardiocytes. Circulation, 93, 1230-1243 (1996).

Kuppuswamy, D., Kerr, C., Narishige, T., Kasi, V.S., Menick, R., and Cooper, G, IV. Association of tyrosine phosphorylated c-Src with the cytoskeleton of hypertrophying myocardium. J. Biol. Chem., 272, 4500-4508 (1997).

Sato, H., Narishige, T., Kuppuswamy, D., Koide, M., Menick, D.R., and Cooper, G. IV. Microtubule stabilization in pressure overload cardiac hypertrophy. J. Cell Biol., 139, 963-973 (1997).

Laser, M., Kasi, V.S., Hamawaki, Cooper, G., M., Kerr, C.M., and Kuppuswamy, D. Differential activation of p70 and p85 S6 kinase isoforms during cardiac hypertrophy in the adult mammal. J. Biol. Chem., 273, 24610-24619 (1998).

Narishige, T., Blade, K.L., Ishibashi, Y., Nagai, T., Hamawaki, M., Menick, D.R., Kuppuswamy, D., and Cooper, G. IV. Cardiac hypertrophy and developmental regulation of the b-tubulin multigene family. J. Biol. Chem., 274, 9692-9697 (1999).

Nagai, T., Laser, M, Baicu, C.F., Zile, R. M., Cooper, G., and Kuppuswamy, D. b3-Integrin-Mediated Focal Adhesion Complex Formation: Studies of Adult Cardiocytes Embedded in a Three-Dimensional Collagen Matrix. Am. J. Cardiol., 83, 38H-43H (1999).

Kasi, V.S., and Kuppuswamy, D. Inhibition of SRC family kinases by a combinatorial action of 5'AMP and small heat shock proteins, both identified from the adult heart. Mol. Cell. Biol., 19, 6858-6871 (1999).

Laser, M., Willey, C.D., Jiang, W., Cooper, G. 4th, Menick, D.R., Zile, M.R., Kuppuswamy, D. Integrin activation and focal complex formation in cardiac hypertrophy. J Biol Chem. Nov 10; 275 (45): 35624-30 (2000).

Book Chapters

Laser, M., Nagai, T., Kasi, V. S., Baicu, C. F., Willey, C. W., Kerr, C. M., Zile, M. R., Cooper, G. IV., and Kuppuswamy, D. Integrin -dependent and -independent signaling during pressure overload cardiac hypertrophy. In: The hypertrophied heart: edited by Takeda, N., Nagano, T.M., and Dhalla, N. S. Kluwer Academic Publishers, Boston, 2000. pp. 143-164.

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Paul J. McDermott, Ph.D.

Wada, H., Zile, M.R., Ivester, C.T., Cooper IV, G., and McDermott, P.J.: Comparative effects of contraction and angiotensin II on growth of adult feline cardiocytes in primary culture. Amer. J. Physiol., 271:H29-H37, 1996.

Tagawa, H., Rozich, J.D., Tsutsui, H., Narishige, T., Kuppuswamy, D., Sato, H., McDermott, P.J., Koide, M., and Cooper IV, G.: Basis for increased microtubules in pressure hypertrophied cardiocytes. Circulation 93:1230-1243, 1996.

Wada, H., Ivester, C.T., Carabello, B.A., Cooper IV, G., and McDermott, P.J.: Translational initiation factor eIF-4E: A link between cardiac load and protein synthesis. J. Biol. Chem., 271:8359-8364, 1996.

Kent R.L., and McDermott, P.J. Passive load and angiotensin II evoke differential responses of gene expression and protein synthesis in cardiac myocytes. Circ. Res. 78:829-838, 1996.

Yang, Q., McDermott, P.J., Duzic, E., Pleij, C.W.A., Sherlock, J.D., and Lanier, S.M.: The 3' untranslated region of the a2C-adrenergic receptor mRNA impedes translation of the receptor message. J. Biol. Chem., 272:15466-15473, 1997.

Makhlouf, A., and McDermott, P.J.: Increased expression of eukaryotic initiation factor 4E during growth of neonatal rat cardiocytes in vitro. Amer. J. Physiol., 274:H2133-H2142, 1998.

Matsuo, T., Carabello, B.A., Nagatomo, Y., Koide, M., Hamawaki, M., Zile, M.R., and McDermott, P.J.: Mechanisms of cardiac hypertrophy in canine volume overload. Am. J. Physiol., 275:H65-H74, 1998.

Tuxworth Jr., W.J., Wada, H., Ishibashi, Y., and McDermott, P.J.: The role of load in regulating eIF-4F complex formation in adult feline cardiocytes. Amer. J. Physiol., 277:H1273-H1282, 1999.

Nagatomo, Y., Carabello, B.A., Hamawaki, M., Nemoto, S., Matsuo, T., and McDermott, P.J.: Translational mechanisms accelerate the rate of cardiac protein synthesis during canine pressure overload hypertrophy. Amer. J. Physiol., In Press.

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Donald R. Menick, Ph.D.

Desrosiers, MG, Gately, LJ, Gambel, AM, Menick, DR. Purification and characterization of the Ca2+-ATPase of Flavobacterium odoratum. J. Biol. Chem. 1996; 271:3945-3951.

Peiffer, WE, Desrosiers, MG, Menick, DR. Cloning and expression of the unique Ca2+-ATPase from Flavobacterium odoratum. J. Biol. Chem. 1996; 271:5095-5100.

Menick, DR, Barnes, KV, Thacker, UF, Dawson, MM, McDermott, DE, Rozich, JD, Kent, RL, Cooper G IV. The exchanger and cardiac hypertrophy. Ann. NY Acad. Sci. 1996; 779:489-501.

Barnes, KV, Dawson, MM, Menick, DR. Initial characterization of the feline sodium- calcium exchanger gene. Ann. NY Acad. Sci. 1996; 779:121-125.

Govindjee, R, Misra, S, Balashov, SP, Ebrey, TG, Crouch, RK, Menick DR. Arginine-82 regulates the pKa of the group responsible for the light-driven proton release in bacteriorhodopsin. Biophys. J. 1996; 71:1011-1023.

Menick, DR, Barnes, KV, Dawson, MM, Kent, RL, Cooper, G IV. Gene expression of the Na-Ca exchanger in cardiac hypertrophy. J. Cardiac Failure 1996; 2(4S):569- 576.

Govindjee, R, Imasheva, ES, Misra, S, Balashov, SP, Ebrey, TG, Chen, N, Menick, DR, Crouch, RK. Mutation of a surface residue, lysine-129, reverses the order of proton release and uptake in bacteriorhodopsin; guanidine hydrochloride restores it. Biophys. J. 1997, 72:886-898.

Kuppuswamy, D, Kerr, C, Narishige, T, Kasi, VS, Menick, DR, Cooper, G IV. Association of tyrosine-phosphorylated c-Src with the cytoskeleton of hypertrophying myocardium. J. Biol. Chem. 1997, 272:4500-4508.

Barnes, KV, Cheng, G, Dawson, MM, Menick, DR. Cloning of the cardiac, kidney, and brain promoters of the feline ncx1 gene. J. Biol. Chem. 1997, 272:11510-11517.

Balashov, SP, Imasheva, ES, Ebrey, TG, Chen, N, Menick, DR, Crouch, RK. Glutamate-194 to cysteine mutation inhibits fast light-induced proton release in bacteriorhodopsin. Biochemistry 36:8671-8676, 1997 (Accelerated publication).

Misra, S, Ebrey, TG, Crouch, RK, Menick, DR. Charge movements in the 13-cis photocycles of the bacteriorhodopsin mutants R82K and R82Q. Photochem. Photobiol. 65:1039-1044, 1997.

Misra, S, Martin, C, Kwon, O-H, Ebrey, TG, Chen, N, Crouch, RK, Menick, DR. Mutation of arginine 134 to lysine alters the pKas of key groups involved in proton pumping by bacteriorhodopsin. Photchem. Photobiol. 66:774-783, 1997.

Sato, H, Nagai, T, Kuppuswamy, D, Narishige, T, Koide, M, Menick, DR, Cooper, G. Microtubule stabilization in pressure overload cardiac hypertrophy. J. Cell Biol. 139:963-973, 1997.

Müller, JG, Nemoto, S, Laser, M, Carabello, BA, Menick, DR. Calcineurin inhibition and cardiac hypertrophy. Science 282:1007a, 1998.

Cheng, G, Hagen, T, Barnes, KV, Dawson, M, Menick, DR. The role of GATA, SRF and a novel element in the regulation of cardiac expression of the Na+-Ca2+ exchanger gene. J Biol Chem 274:12819-12826. 1999.

Balashov, SP, Lu, M, Imasheva, ES, Govindjee, R, Othersen, B, III, Crouch, RK, Menick, DR. The proton release group of bacteriorhodopsin controls the rate of the final step of its photocycle at low pH. Biochemistry 38:2026-2039, 1999.

Narishige, T, Blade, KL, Ishibashi, Y, Nagai, T, Hamawaki, M, Menick, DR, Kuppuswamy, D, Cooper, G. Cardiac hypertrophic and developmental regulation of the b-tubulin multigene family. J Biol Chem. 274:9692-7 1999.

Blade, K, Menick, DR, Cabral, F. Overexpression of class I, II, or IVb b-tubulin isotypes in CHO cells is insufficient to confer resistance to paclitaxel. J. Cell Science, Jul;112 ( Pt 13):2213-21 1999.

Gonzalez-Garay, ML, Chang, L, Blade, K, Menick, DR, Cabral, F. A leucine cluster in b-tubulin that is involved in paclitaxel resistance. J. Biol. Chem. 274(34):23875-82 1999.

Laser, M., Willey, C.D., Jiang, W., Cooper, G. 4th, Menick, D.R., Zile, M.R., Kuppuswamy, D. Integrin activation and focal complex formation in cardiac hypertrophy. J Biol Chem. Nov 10; 275 (45): 35624-30 (2000).

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Terrence X. O'Brien, M.D., F.A.C.C.

Thompson, JT, Rackley, MS, O'Brien, TX: Up-regulation of the cardiac homeobox gene Nkx2.5 (CSX) in feline right ventricular pressure overload. American Journal of Physiology 1998; 274:H1569-H1573.

O'Brien, TX, Schuyler, GT, Rackley, MS and Thompson, JT: F1-ATP synthase beta-subunit and cytochrome c transcriptional regulation in right ventricular hemodynamic overload and hypertrophically stimulated cardiocytes. Journal of Molecular and Cellular Cardiology 1999, 31:167-178.

Paul, SC and O'Brien, TX: Chest x-ray and vascular studies. Chapter in Primary Care Management of Heart Disease in Primary Care Practice, Taylor, GJ (ed), Mosby, 2000.

Thompson, JT and OíBrien, TX: Cardiovascular Genetic Diseases, Chapter in Primary Care Management of Heart Disease in the Primary Care Practice, Taylor, GJ (ed), Mosby, 2000.

Usher, BW and O'Brien TX. Recent advances in dobutamine stress echocardiography. Clinical Cardiology 2000; In press.

Muller JG, Thompson JT, Rackley MS, McQuinn TC, Menick DR, O'Brien TX. Co-regulation of Nkx2-5 and serum response factor induced activation of the cardiac sodium-calcium exchanger promoter. Journal of Molecular and Cellular Cardiology, In revision.

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Michael Zile, M.D.

Tanaka R, Barnes MA, Cooper G,IV, Zile MR: Effects of anisosmotic stress on adult mammalian cardiac muscle length, diameter, area, and sarcomere length. Am J Physiol, 270 :H1414-H1422, 1996.

Wada H, Zile MR, Ivester CT, Cooper G, IV, McDermott PJ: Comparative effects of contraction and angiotensin II on growth of adult feline cardiocytes in primary culture. Am J Physiol, 271: H29 - H37, 1996.

Kato S, Koide M, Cooper G, IV, Zile MR: Effects of pressure or volume overload hypertrophy on passive stiffness in isolated adult mammalian cardiac muscle cells. Am J Physiol, 271: H2575 - H2583, 1996.

Tagawa H, Wang N, Narishige T, Ingber DE, Zile MR, Cooper G, IV: Cytoskeletal mechanics in pressure overload cardiac hypertrophy. Circ Res, 80:281 - 289, 1997.

Koide M, Nagatsu M, Zile MR, Hamawaki M, Swindle M, Keech G, DeFreyte G, Tagawa H, Cooper G, IV, Carabello B: Premorbid determinants of left ventricular dysfunction in a novel model of gradually induced pressure overload in the adult canine. Circulation, 95:1601-1610, 1997.

Gramling-Babb P, Miller MJ, Reeves ST, Roy RC, Zile MR: Treatment of medically and surgically refractory angina pectoris with high thoracic epidural analgesia: Initial clinical experience. Am Heart Journal, 134:648-55, 1997.

Tagawa H, Koide M, Sato H, Zile MR, Carabello BA, Cooper G IV: Cytoskeletal role in the transition from compensated to decompensated hypertrophy after adult canine left ventricular pressure overloading. Circ Res, 82:751-761, 1998.

Matsuo T, Carabello BA, Nagatomo Y, Koide M, Hamawaki M, Zile MR, McDermott PJ: Mechanisms of cardiac hypertrophy in canine volume overload. Am J Physiol, 275: H65 - H74, 1998.

Goldfine H, Aurigemma GP, Zile MR, Gaasch WH: Left ventricular length-force- shortening relationships before and after surgical correction of chronic mitral regurgitation. J Am Coll Cardiol, 31: 180 - 185, 1998.

Zile MR, Cowles MK, Buckley JM, Richardson K, Cowles B, Baicu CF, Cooper G IV, Gharpuray V: Gel stretch method: A new method to measure constitutive properties of cardiac muscle cells. Am J Physiol, 274: H2188 - H2202, 1998.

Zile MR, Richardson K, Cowles MK, Buckley JM, Koide M, Cowles B, Gharpuray V, Cooper G IV: Constitutive Properties of Adult Mammalian Cardiac Muscle Cells. Circulation, 98:567-579, 1998.

Hamawaki M, Coffman TM, Lashus A, Koide M, Zile MR, Oliverio MI, Defreyte G, Cooper G, IV, Carabello, BA: Pressure overload hypertrophy is unabated in mice devoid of AT1A receptors: Am J Physiol, 274: H868 - H873, 1998.

Gramling-Babb P, Zile MR, Duc TA, Reeves ST: A novel treatment for intractable angina: High thoracic epidural analgesia. Published on the Internet at site: http:/www.ispub.com/journals/IJA/Vol2N1/angina.htm. 1998

Koide M, Carabello BA, Conrad CC, Buckley JM, Defreyte G, Barnes M, Tomonek RJ, Cooper, G IV, Zile MR: Hypertrophic response to hemodynamic overload: Role of load versus renin angiotensin system activation. Am J Physiol, 276: H350-H358, 1999.

Zile MR, Koide M, Sato H, Ishiguro Y, Conrad CC, Buckley JM, Morgan JP, Cooper G IV: Role of Microtubules in the Contractile Dysfunction of Hypertrophied Myocardium. J Am Coll Cardiol, 33:250-260, 1999.

Nagai T, Laser M, Baicu CF, Zile MR, Cooper G, Kuppuswamy D: b3-Integrin-mediated adhesion complex formation: adult cardiocytes embedded in three-dimensional polymer matrices. Am J Cardiol, 83:38H-43H, 1999

Spinale FG, Coker ML, Krombach SR, Mukherjee R, Hallak H, Houck WV, Clair MJ, Kribbs SB, Johnson LL, Peterson JT, Zile MR: Matrix metalloproteinase inhibition during the development of congestive heart failure: effects on left ventricular dimensions and function. Circ Res, 85:364-376, 1999.

Yun KL, Sintek CF, Schuyler GT, Fletcher AD, Pfeffer TA, Kochamba GS, Miller DC, Kohnsari S, Zile MR: Mitral valve replacement with partial vs complete chordal preservation: a randomized trial. Circulation, In press, 1999.

Koide M, Hamawaki M, Narishige T, Sato H, Defreyte G, Zile MR, Cooper G IV, Carabello BA: Microtubule depolymerization normalizes in vivo and in vitro myocardial contractile function in dogs with pressure overload left ventricular hypertrophy. Circulation, Under review, 1999.

Roten L, Nemoto S, Simsic J, Coker ML, Rao J, Baicu S, Defreyte G, Solloway PJ, Zile MR, Spinale FG: Effects of gene deletion of the tissue inhibitor of the matrix metalloproteinase-type 1 (TIMP-1) on left ventricular geometry and function in mice. Am J Physiol. in press, 1999.

McElmurray JH, Mukherjee R, New RB, Sampson AC, King MK, Hendrick JW, Goldberg A, Peterson TJ, Hallak H, Zile MR, Spinale FG: Angiotensin converting enzyme and matrix metalloproteinase inhibition with developing heart failure: comparative effects on left ventricular function and geometry. J Pharm and Exp Therapeutics, In press 1999.

Zile MR, Green R, Schuyler GT, Aurigemma G, Miller C, Cooper G, IV: Mechanisms causing myocardial failure in man: Cytoskeletal changes in patients with pressure overload hypertrophy (POH). Circulation, Under Review, 1999.

Harris TS, Baicu CF, Conrad CH, Zile MR: Constitutive properties of hypertrophied myocardium: Cellular contributions to changes in myocardial stiffness and viscosity. Under Review, 1999.

Simsic J, Nemoto S, Cooper G, IV, Schuyler GT, De Freyte G, Ingwall JS, Zile MR: Effects of M-creatine kinase deletion on in vivo murine cardiac contractile function and reserve. Under Review, 1999.

Laser, M., Willey, C.D., Jiang, W., Cooper, G. 4th, Menick, D.R., Zile, M.R., Kuppuswamy, D. Integrin activation and focal complex formation in cardiac hypertrophy. J Biol Chem. Nov 10; 275 (45): 35624-30 (2000).

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