Michael Zile, M.D.

Michael Zile, M.D.

Principal Investigator at the Gazes Cardiac Research Institute
Professor of Medicine at the Medical University of South Carolina, and the Director of the Medical Intensive Care Unit at the Ralph H. Johnson Department of Veterans Affairs Medical Center

Medical University of South Carolina, Department of Medicine, Division of Cardiology, Suite 816, Clinical Science Building, PO Box 250623, Charleston, SC 29425

Phone: (843) 792 - 4457 / Fax: (843) 792 - 7771
E-mail: zilem@musc.edu

EDUCATION:

Knox College; B.S.

Rush University; M.D.

Residencies & Postgraduate Education

Residency in Internal Medicine; Rush Presbyterian-St. Lukes Medical College; Chicago, IL

Cardiology Fellow; Tufts-New England Medical Center; Boston, MA

Research Interest:

1) Identifying the basic myocardial, cellular, extracellular, and molecular mechanisms causing diastolic heart failure, 2) developing new treatment strategies to treat diastolic heart failure, 3) defining the transsarcolemmal and intracellular signal transduction mechanisms which modulate myocardial, extracellular matrix and cardiomyocyte growth. His laboratory is supported by grants from the National Heart, Lung and Blood Institute, the American Heart Association, the Department of Veterans Affairs and the Medical University of South Carolina.

Laboratory Members

Catalin Baicu, Ph.D.

Tim Brooks

Elizabeth Hapke

Weems Pennington, Ph.D.

Fei Qiao, M.D.

An Van Laer

Past Laboratory Members

Yukihisa Isomatsu, M.D.

Virginia Livesay

Steven Pellegrino

Janet Simsic, M.D.

Jason Stroud

Brian Wall

Valerie Young

Recent Publications:

Tanaka R, Barnes MA, Cooper G,IV, Zile MR: Effects of anisosmotic stress on adult mammalian cardiac muscle length, diameter, area, and sarcomere length. Am J Physiol, 270 :H1414-H1422, 1996.

Wada H, Zile MR, Ivester CT, Cooper G, IV, McDermott PJ: Comparative effects of contraction and angiotensin II on growth of adult feline cardiocytes in primary culture. Am J Physiol, 271: H29 - H37, 1996.

Kato S, Koide M, Cooper G, IV, Zile MR: Effects of pressure or volume overload hypertrophy on passive stiffness in isolated adult mammalian cardiac muscle cells. Am J Physiol, 271: H2575 - H2583, 1996.

Tagawa H, Wang N, Narishige T, Ingber DE, Zile MR, Cooper G, IV: Cytoskeletal mechanics in pressure overload cardiac hypertrophy. Circ Res, 80:281 - 289, 1997.

Koide M, Nagatsu M, Zile MR, Hamawaki M, Swindle M, Keech G, DeFreyte G, Tagawa H, Cooper G, IV, Carabello B: Premorbid determinants of left ventricular dysfunction in a novel model of gradually induced pressure overload in the adult canine. Circulation, 95:1601-1610, 1997.

Gramling-Babb P, Miller MJ, Reeves ST, Roy RC, Zile MR: Treatment of medically and surgically refractory angina pectoris with high thoracic epidural analgesia: Initial clinical experience. Am Heart Journal, 134:648-55, 1997.

Tagawa H, Koide M, Sato H, Zile MR, Carabello BA, Cooper G IV: Cytoskeletal role in the transition from compensated to decompensated hypertrophy after adult canine left ventricular pressure overloading. Circ Res, 82:751-761, 1998.

Matsuo T, Carabello BA, Nagatomo Y, Koide M, Hamawaki M, Zile MR, McDermott PJ: Mechanisms of cardiac hypertrophy in canine volume overload. Am J Physiol, 275: H65 - H74, 1998.

Goldfine H, Aurigemma GP, Zile MR, Gaasch WH: Left ventricular length-force- shortening relationships before and after surgical correction of chronic mitral regurgitation. J Am Coll Cardiol, 31: 180 - 185, 1998.

Zile MR, Cowles MK, Buckley JM, Richardson K, Cowles B, Baicu CF, Cooper G IV, Gharpuray V: Gel stretch method: A new method to measure constitutive properties of cardiac muscle cells. Am J Physiol, 274: H2188 - H2202, 1998.

Zile MR, Richardson K, Cowles MK, Buckley JM, Koide M, Cowles B, Gharpuray V, Cooper G IV: Constitutive Properties of Adult Mammalian Cardiac Muscle Cells. Circulation, 98:567-579, 1998.

Hamawaki M, Coffman TM, Lashus A, Koide M, Zile MR, Oliverio MI, Defreyte G, Cooper G, IV, Carabello, BA: Pressure overload hypertrophy is unabated in mice devoid of AT1A receptors: Am J Physiol, 274: H868 - H873, 1998.

Gramling-Babb P, Zile MR, Duc TA, Reeves ST: A novel treatment for intractable angina: High thoracic epidural analgesia. Published on the Internet at site: http:/www.ispub.com/journals/IJA/Vol2N1/angina.htm. 1998

Koide M, Carabello BA, Conrad CC, Buckley JM, Defreyte G, Barnes M, Tomonek RJ, Cooper, G IV, Zile MR: Hypertrophic response to hemodynamic overload: Role of load versus renin angiotensin system activation. Am J Physiol, 276: H350-H358, 1999.

Zile MR, Koide M, Sato H, Ishiguro Y, Conrad CC, Buckley JM, Morgan JP, Cooper G IV: Role of Microtubules in the Contractile Dysfunction of Hypertrophied Myocardium. J Am Coll Cardiol, 33:250-260, 1999.

Nagai T, Laser M, Baicu CF, Zile MR, Cooper G, Kuppuswamy D: b3-Integrin-mediated adhesion complex formation: adult cardiocytes embedded in three-dimensional polymer matrices. Am J Cardiol, 83:38H-43H, 1999

Spinale FG, Coker ML, Krombach SR, Mukherjee R, Hallak H, Houck WV, Clair MJ, Kribbs SB, Johnson LL, Peterson JT, Zile MR: Matrix metalloproteinase inhibition during the development of congestive heart failure: effects on left ventricular dimensions and function. Circ Res, 85:364-376, 1999.

Yun KL, Sintek CF, Schuyler GT, Fletcher AD, Pfeffer TA, Kochamba GS, Miller DC, Kohnsari S, Zile MR: Mitral valve replacement with partial vs complete chordal preservation: a randomized trial. Circulation, In press, 1999.

Koide M, Hamawaki M, Narishige T, Sato H, Defreyte G, Zile MR, Cooper G IV, Carabello BA: Microtubule depolymerization normalizes in vivo and in vitro myocardial contractile function in dogs with pressure overload left ventricular hypertrophy. Circulation, Under review, 1999.

Roten L, Nemoto S, Simsic J, Coker ML, Rao J, Baicu S, Defreyte G, Solloway PJ, Zile MR, Spinale FG: Effects of gene deletion of the tissue inhibitor of the matrix metalloproteinase-type 1 (TIMP-1) on left ventricular geometry and function in mice. Am J Physiol. in press, 1999.

McElmurray JH, Mukherjee R, New RB, Sampson AC, King MK, Hendrick JW, Goldberg A, Peterson TJ, Hallak H, Zile MR, Spinale FG: Angiotensin converting enzyme and matrix metalloproteinase inhibition with developing heart failure: comparative effects on left ventricular function and geometry. J Pharm and Exp Therapeutics, In press 1999.

Zile MR, Green R, Schuyler GT, Aurigemma G, Miller C, Cooper G, IV: Mechanisms causing myocardial failure in man: Cytoskeletal changes in patients with pressure overload hypertrophy (POH). Circulation, Under Review, 1999.

Harris TS, Baicu CF, Conrad CH, Zile MR: Constitutive properties of hypertrophied myocardium: Cellular contributions to changes in myocardial stiffness and viscosity. Under Review, 1999.

Simsic J, Nemoto S, Cooper G, IV, Schuyler GT, De Freyte G, Ingwall JS, Zile MR: Effects of M-creatine kinase deletion on in vivo murine cardiac contractile function and reserve. Under Review, 1999.
Laser, M., Willey, C.D., Jiang, W., Cooper, G. 4th, Menick, D.R., Zile, M.R., Kuppuswamy, D. Integrin activation and focal complex formation in cardiac hypertrophy. J Biol Chem. Nov 10; 275 (45): 35624-30 (2000).

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