George Cooper, IV, M.D.

George Cooper, IV, M.D.

Principal Investigator and Director at the Gazes Cardiac Research Institute

Gazes Cardiac Research Institute, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29403

Phone: (843) 876 - 5066 Office / Fax: (843) 876 - 5068
E-mail: cooperge@musc.edu

EDUCATION:

1960 Graduate, The Episcopal High School, Alexandria, Virginia
1964 B.A., Williams College, Williamstown, Massachusetts
1968 M.D., Cornell University Medical College, New York, NY

Postgraduate Education

1968-69 Intern in Medicine, University Hospitals, Cleveland, Ohio
1969-70 Assistant Resident in Medicine, University Hospitals, Cleveland, Ohio
1970-71 Senior Assistant Resident in Medicine, University Hospitals, Cleveland, Ohio
1969-71 Teaching Fellow in Medicine, University Hospitals, Cleveland, Ohio
1971-73 Research Fellow, Department of Physiology, Mayo Clinic, Rochester, Minnesota
1973-75 Cardiology Fellow, Duke University Medical Center, Durham, North Carolina
Research Interest:

Cardiovascular physiology, cellular and molecular biology, biochemistry, pharmacology, biomedical engineering, and anatomy.

Laboratory Members

Uri Camens

Guangmao Cheng, M.D.

Kristan Murray

James Hill

Justin Scruggs

Masaru Takahashi, M.D.

Past Laboratory Members

Mary Barnes

Benzina Franklin

Sebette Hamill

Yoshihiro Iijima, M.D.

Yuji Ishibashi

Barbara M. Rembiesa

Brian Wall

Bill Vatter

Recent Publications:

Tanaka, R., Barnes, M.A., Cooper, G., and Zile, M.R.: Effects of Anisosmotic Stress on Cardiac Muscle Cell Length, Diameter, Area, and Sarcomere Length. Am. J. Physiol., 270: H1414-1422, 1996.
Tagawa, H., Rozich, J.D., Narishige, T., Kuppuswamy, D., Tsutsui, H., McDermott, P.J., Koide, M., and Cooper, G.: Basis for Increased Microtubules in Pressure Hypertrophied Cardiocytes. Circulation, 93: 1230-1243, 1996.
Tagawa, H., Koide, M., Sato, H., and Cooper, G.: Cytoskeletal Role in the Contractile Dysfunction of Cardiocytes from Hypertrophied and Failing Right Ventricular Myocardium. Proc. Assoc. Am. Physicians, 108: 218-229, 1996.
Wada, H., Ivester, C.T., Carabello, B.A., Cooper, G., and McDermott, P.J.: Translation Initiation Factor eIF-4E: A Link Between Cardiac Load and Protein Synthesis. J. Biol. Chem., 271: 8359-8364, 1996.
Menick, D.R., Barnes, K.V., Thacker, U.F., Dawson, M.M., McDermott, D.E., Rozich, J.D., Kent, R.L., and Cooper, G.: The Exchanger and Cardiac Hypertrophy. Ann. NY Acad. Sci., 779: 489-501, 1996.
Wada, H., Zile, M.R., Ivester, C.T., Cooper, G., and McDermott, P.J.: Comparative Effects of Contraction and Angiotensin II on Growth of Adult Feline Cardiocytes in Primary Culture. Am. J. Physiol., 271: H29-37, 1996.
Cooper, G.: Basic Mechanisms of Myocardial Hypertrophy: A Review of Molecular Mechanisms. Annu. Rev. Med., 48: 13-23, 1997.
Menick, D.R., Barnes, K.V., Dawson, M.M., Kent, R.L., and Cooper, G.: Gene Expression of the Na-Ca Exchanger in Cardiac Hypertrophy. J. Cardiac Failure, 2: 569-576, 1996.
Kato, S., Koide, M., Cooper, G., and Zile, M.R.: Effects of Pressure or Volume Overload Hypertrophy on Passive Stiffness in Isolated Adult Cardiac Muscle Cells. Am. J. Physiol., 271: H2575-2583, 1996.
Tagawa, H., Wang, N., Narishige, T., Ingber, D.E., Zile, M.R., and Cooper, G.: Cytoskeletal Mechanics in Pressure Overload Cardiac Hypertrophy. Circ. Res., 80: 281-289, 1997.
Kuppuswamy, D., Kerr, C., Narishige, T., Kasi, V.S., Menick, D.R., and Cooper, G.: Association of Tyrosine Phosphorylated pp60c-Src with the Cytoskeleton of Hypertrophying Myocardium. J. Biol. Chem., 272: 4500-4508, 1997.
Koide, M., Nagatsu, M., Zile, M.R., DeFreyte, G., Tagawa, H., Cooper, G., and Carabello, B.A.: Premorbid Determinants of Left Ventricular Dysfunction in a Novel Model of Gradually Induced Pressure Overload in the Adult Canine. Circulation, 95: 1601-1610, 1997.
Sato, H., Nagai, T., Kuppuswamy, D., Narishige, T., Koide, M., Menick, D.R., and Cooper, G.: Microtubule Stabilization in Pressure Overload Cardiac Hypertrophy. J. Cell. Biol., 139: 963-973, 1997.
Zile, M.R., Richardson, K., Cowles, M.K., Buckley, J.M., Koide, M., Cowles, B.A., Gharpuray, V., and Cooper, G.: Constitutive Properties of Adult Mammalian Cardiac Muscle Cells. Circulation, 98: 567-579, 1998.
Hamawaki, M., Coffman, T.M., Lashus, A., Koide, M., Zile, M.R., Oliverio, M.I., DeFreyte, G., Cooper, G., and Carabello, B.A.: Pressure Overload Hypertrophy Is Unabated in Mice Devoid of AT1A Receptors. Am. J. Physiol., 274: H868-873, 1998.
Tagawa, H., Koide, M., Sato, H., Zile, M.R., Carabello, B.A., and Cooper, G.: Cytoskeletal Role in the Transition from Compensated to Decompensated Hypertrophy During Adult Canine Left Ventricular Pressure Overloading. Circ. Res., 82: 751-761, 1998.
Zile, M.R., Cowles, M.K., Buckley, J.M., Richardson, K., Cowles, B.A., Baicu, C.F., Cooper, G., and Gharpuray, V.: Gel Stretch Method: A New Method to Measure Constitutive Properties of Cardiac Muscle Cells. Am. J. Physiol., 274: H2188-2202, 1998.
Laser, M., Kasi, V.S., Hamawaki, M., Cooper, G., Kerr, C.M., and Kuppuswamy, D.: Differential Activation of p70 and p85 S6 Kinase Isoforms during Cardiac Hypertrophy in the Adult Mammal. J. Biol. Chem., 273: 24610-24619, 1998.
Zile, M.R., Koide, M., Sato, H., Ishiguro, Y., Conrad, C.H., Buckley, J.M., Morgan, J.P., and Cooper, G.: Role of Microtubules in the Contractile Dysfunction of Hypertrophied Myocardium. J. Am. Coll. Cardiol., 33: 250-260, 1999.
Nagai, T., Laser, M., Baicu, C.F., Zile, M.R., Cooper, G., and Kuppuswamy, D.: b3-Integrin-Mediated Focal Adhesion Complex Formation: Adult Cardiocytes Embedded in Three-Dimensional Polymer Matrices. Am. J. Cardiol., 83: 38H-43H, 1999.
Koide, M., Carabello, B.A., Conrad, C.C., Buckley, J.M., DeFreyte, G., Barnes, M., Tomanek, R.J., Wei, C.C., Dell'Italia, L.J., Cooper, G., and Zile, M.R.: Hypertrophic Response to Hemodynamic Overload: Role of Load vs. Renin-Angiotensin System Activation. Am. J. Physiol., 276: H350-358, 1999.
Narishige, T., Blade, K.L., Ishibashi, Y., Nagai, T., Hamawaki, M., Menick, D.R., Kuppuswamy, D., and Cooper, G.: Cardiac Hypertrophic and Developmental Regulation of the b-Tubulin Multigene Family. J. Biol. Chem., 274: 9692-9697, 1999.
Nagatsu, M., Spinale, F.G., Koide, M., Tagawa, H., DeFreitas, G., Cooper, G., and Carabello, B.A.: Bradycardia and the Role of b-Blockade in the Amelioration of Left Ventricular Dysfunction. Circulation, 101: 653-659, 2000.

Papers Submitted or In Preparation

Rackley, M.S., Thompson, J.T., Hamawaki, M., McDermott, P.J., Cooper, G., and O'Brien, T.X.: Early Initiation Factor 2-a Is Upregulated During Cardiac Hypertrophy Induced by Hemodynamic Pressure Overload. Am. J. Physiol., Submitted.
Zile, M.R., Buckley, J.M., Tagawa, H., Richardson, K., Cowles, M.K., Gharpuray, V., Koide, M., and Cooper, G.: Effects of Pressure Overload Hypertrophy on Passive Stiffness and Viscous Damping in Adult Mammalian Cardiac Muscle Cells. Biophys. J., Submitted.
O'Brien, T.X., Menick, D.R., Rackley, M.S., McDermott, P.J. and Cooper, G.: F1-ATP Synthase Activation by Right Ventricular Load and Enhancer Inducibility in Cardiocytes. Am. J. Physiol., Submitted.
Koide, M., Hamawaki, M.. Narishige, T., Sato, H., DeFreyte, G., Cooper, G., and Carabello, B.A.: Microtubule Depolymerization Normalizes Ventricular Contractile Dysfunction in Intact Dogs with Left Ventricular Hypertrophy. J. Clin. Invest., Submitted.
Zile, M.R., Green, G.R., Schuyler, G.T., Aurigemma, G.P., Miller, D.C., and Cooper, G.: Cytoskeletal Changes in Patients with Left Ventricular Pressure Overload Hypertrophy. N. Engl. J. Med., Submitted.

Laser, M., Willey, C.D., Jiang, W., Cooper, G. 4th, Menick, D.R., Zile, M.R., Kuppuswamy, D. Integrin activation and focal complex formation in cardiac hypertrophy. J Biol Chem. Nov 10; 275 (45): 35624-30 (2000).

Book Chapters

Menick, D.R., Barnes, K.V., Dawson, M.M., Kent, R.L., and Cooper, G.: Regulation of the Na-Ca Exchanger Expression in Cardiac Hypertrophy. In: Heart Failure: New Insights into Mechanisms and Management. Eds.: S. Sasayama, J. Ross, Jr., and D.L. Brutsaert. Churchill Livingstone, Tokyo, Japan, 1996, pp. 69-76.
Laser, M., Nagai, T., Kasi, V.S., Baicu, C.F., Wiley, C.D., Zile, M.R., Cooper, G., and Kuppuswamy, D.: Integrin-Dependent and -Independent Signaling during Pressure Overload Hypertrophy. In: The Hypertrophied Heart. Eds.: Takeda, N., Nagano, M., and Dhalla, K. Kluwer Academic Publishers, Boston, MA, 1999.

Reviews

Cooper, G.: What Is the Stimulus to Cardiac Growth? ACCEL, 28: 1997.
Cooper, G.: Basic Mechanisms of Myocardial Hypertrophy: A Review of Molecular Mechanisms. Annu. Rev. Med., 48: 13-23, 1997.
Tsutsui, H., Tagawa, H., Cooper, G., and Takeshita, A.: Role of Microtubules in the Transition from Compensated Cardiac Hypertrophy to Failure. Heart Failure Reviews, In press.

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