Molecular and Cellular Mechanisms of Myocardial Remodeling
Thomas CV, Coker ML, Zellner JL, Handy JR, Crumbley III AJ, Spinale FG. Increased matrix metalloproteinase activity and selective upregulation in LV myocardium from patients with end-stage dilated cardiomyopathy. Circulation,1998:97: 1708-1715

Spinale FG, Coker ML, Thomas CV, Walker JD, Mukherjee R, Hebbar L. Time dependent changes in matrix metalloproteinase activity and expression during the progression of congestive heart failure; relation to ventricular and myocyte function. Circulation Research, 1998; 82:482-495

Coker ML, Doscher MA, Thomas CV, Galis ZS, Spinale FG. Matrix metalloproteinase activity and expression in isolated LV myocyte preparations. Am J Physiol, 1999; 277 (Heart Circ. Physiol. 46): H777-H787

Mann DL, Spinale FG. Activation of matrix metalloproteinases in the failing human heart. Circulation, 1998;98:1699-1702

Spinale FG, Krombach RS, Coker ML, Mukherjee R, Thomas CV, Houck WV, Clair MJ, Kribbs SB, Johnson LL, Peterson JT. Matrix metalloproteinase inhibition during developing congestive heart failure in pigs: Effects on left ventricular geometry and function. Circulation Research, 1999; 85:364-376

Roten L, Nemoto S, Simsic J, Coker ML, Rao V, Baicu S, Defreyte G, Soloway PJ, Zile MR, Spinale FG. Effects of gene deletion of the tissue inhibitor of the matrix metalloproteinase-type 1 (TIMP-1) on left ventricular geometry and function in mice. J Mol Cell Cardiol 2000 32, 109-120

Spinale FG, Coker ML, Heung LJ, Bond BR, Gunasinghe HR, Etoh T, Goldberg AT, Zellner JL, Crumbley AJ. A matrix metalloproteinase induction/activation system exists in the human left ventricular myocardium and is upregulated in heart failure. Circulation, in press

Development of Therapies for Heart Failure
Spinale FG, Mukherjee R, Krombach RS, Clair MJ, Hendrick JW, Houck WV, Hebbar L, Kribbs SB, Zellner JL, Dodd MG. Chronic amlodipine treatment during the development of congestive heart failure in pigs: hemodynamic, contractile and neurohormonal effects. Circulation, 1998:98:1666-1674

Houck WV, Pan LC, Kribbs SB, Clair MJ, McDaniel GM, Krombach RS, Merritt WM, Pirie C, Mukherjee R, Spinale FG. The effects of growth hormone supplementation on left ventricular and myocyte function with the development of congestive heart failure. Circulation, 1999: 100: 2003-2009

Spinale FG, Coker ML, Bond BR, Zellner JL. Myocardial matrix degradation and metalloproteinase activation in the failing heart: A potential therapeutic target, Cardiovasc Res, 2000 May 1; 46 (2): 225-238

Bond BR, Zellner JL, Dorman BH, Multani MM, Kratz JM, Crumbley AJ, Crawford FA, Spinale FG. Differential effects of calcium channel antagonists in the amelioration of radial artery vasospasm. Ann Thorac Surg. 2000 Apr;69(4):1035-40

Preventions/Protection from Heart Failure Following Cardiac Surgery
New RB, Zellner JL, Hebbar L, Mukherjee R, Sampson AC, Hendrick JW, Handy JR, Crawford FA, Spinale FG. Isolated left ventricular myocyte contractility in patients undergoing cardiac operations. J Thorac Cardiovasc Surg, 1998;116:495-502

Dorman HB, Hebbar L, Zellner JL, New RB, Houck WV, Acsell J, Nettles C, Hendrick JW, Sampson AP, Mukherjee R, Spinale FG. ATP-sensitive potassium channel activation before cardioplegia: Effects on ventricular and myocyte function. Circulation, 1998;98:II-176-II-183

Walker CA, Spinale FG. The structure and function of the cardiac myocyte: a review of fundamental concepts. J Thorac Cardiovasc Surg, 1999, 118: 375-382

Spinale FG. Cellular and molecular therapeutic targets for treatment of contractile dysfunction following cardioplegic arrest. Ann Thor Surg, 1999 Nov; 68 (5): 1934-41

Walker CA, Crawford FA, Spinale FG. Myocyte contractile dysfunction with hypertrophy and failure: relevance to cardiac surgery. J Thorac Cardiovasc Surg, 2000 Feb; 199 (2): 388-400

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