Sunday, November 15

2:00-6:00 pm Registration Check-In

6:00-7:30 pm Dinner

7:30 pm Welcome and Introductory Remarks

SESSION 1: Mechanisms of Uncoupling (David G. Nicholls, Chair)

7:45-8:10 pm Proton Leak Pathways

Martin D. Brand, Buck Institute

8:10-8:35 pm Ethanol-Induced Mitochondrial Depolarization in Liver

Zhi Zhong, Medical University of South Carolina

8:35-9:00 pm Uncoupling Proteins, Thermogenesis and Reactive Oxygen

Jan Nedergaard, Stockholm University

9:00-9:30 pm Poster Abstract Presentations

9:00-9:15 pm The Effect of Caloric Restriction (CR) and Mild Mitochondrial Uncoupling on Mitochondrial Biogenesis, Enos Activity and Antioxidants Defenses

Fernanda Cerqueira, Universidade due Sᾶo Paulo

9:15-9:30 pm Uncoupling Protein 1 is a Hydroxide (OH-) Ion Channel

Yuriy Kirichok, University of California

Monday, November 16

7:00-7:50 am Breakfast and Registration Check-In

8:00-8:10am Raymond S. Greenberg, President, MUSC - Welcome

SESSION 2: Mitochondrial Channels (John J. Lemasters, Chair)

8:10-8:35 am Mitochondrial Permeability Transition: the Pore and Its Consequences
Andrew P. Halestrap, University of Bristol

8:35-9:00 am Structure-Function of the Voltage Dependent Anion Channel

Gerhard Wagner, Harvard Medical School

9:00-9:25 am VDAC Regulation by Cytosolic Proteins

Tatiana K. Rostovtseva, NIH

9:25-9:50 am 3D Structures of the VDAC channel: Native or Not?

Marco Colombini, University of Maryland

9:50-10:00 am Group Photo

10:00-10:10 am Break

SESSION 3 Mitochondrial Dynamics and Autophagy (Orian Shirihai, Chair)

10:15-10:40 am Mitochondrial Quality Control with Mitophagy

Atsushi Tanaka, NIH

10:40-11:05 am Mitochondrial Permeability Transition, Mitophagy and Hepatocyte Remodeling

John J. Lemasters, Medical University of South Carolina

11:05-11:30 am Mitochondrial Calcium Signaling and Motility

Gyorgy Hajnóczky, Thomas Jefferson University

11:30-12:00 Poster Abstract Presentations

11:30-11:45 Free Tubulin and cAmp-Dependent Phosphorylation Modulate Mitochondrial Membrane Potential in HEPG2 Cells: Is VDAC the Target?

Eduardo N. Maldonado, Medical University of South Carolina

11:45-12:00n Mitochondrial Fusion is Required for Extension of Chronological Life Span by Caloric Restriction in S. Cerevisiae

Arnold Seo, University of Florida

12:00-1:50 pm Lunch

2:00-4:00 pm Workshop: Proteomics (Craig C. Beeson, Chair)

Proteomics to Probe Mitochondrial Metabolism Pathways

Lesley Kane, Johns Hopkins University

New Approaches to Proteomic Analysis

Daniel Knapp, Medical University of South Carolina

Identifying New Components of the Permeability Transition Pore

Christopher P. Baines, University of Missouri-Columbia

Poster Abstract Presentations:

Regulation of Mitochondrial Translation by Reversible Acetylation

Emine C. Koc, Pennsylvania State University

4:00-6:00 pm Poster Viewing (Odd Numbered Posters Presenting)

6:00 – 7:30 pm Dinner

SESSION 4: Beta Cell Function and Metabolic Syndrome (Jan Nedergaard, Chair)

7:45-8:10 pm UCP2 in Steatohepatitis

Kenneth D. Chavin, Medical University of South Carolina

8:10-8:35 pm Control of Energy Transduction: Implications for Obesity

Mary Ellen Harper, University of Ottawa

8:35-9:00 pm Mitochondrial Calcium in the Coupling of Metabolism to Insulin Secretion

Claes B. Wollheim, University of Geneva

9:00-9:30 pm Poster Abstract Presentations

9:00-9:15 pm Uncoupling Protein-2 Attenuates Glucose-Stimulated Insulin Secretion in INS-1E Insulinoma Cells by Dampening Mitochondrial Production of Reactive Oxygen Species

Charles Affourtit, Buck Institute for Age Research

9:15-9:30 pm Glucose Availability Modulates Mitochondrial Sources of NADPH in Skeletal Muscle Cells: Implications for Oxidative Stress

Ryan Mailloux, University of Ottawa

Tuesday, November 17

7:00-7:50 am Breakfast

SESSION 5: Oxidative Stress and Aging (Hartmut Jaeschke, Chair)

8:00-8:25 am Oxidative Stress and Alcoholic Hepatotoxicity

Shannon M. Bailey, University of Alabama at Birmingham

8:25-8:50 am Mitochondria, Free Radicals and Aging

Holly Van Remmen, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio

8:50-9:15 am Mitochondrial Calpain in Aging

Rick G. Schnellmann, Medical University of South Carolina

9:15-9:40 am Sirtuins, Mitochondrial Acetylation, Calorie Restriction, and Aging

David B. Lombard, University of Michigan

9:40-10:10 am Break

SESSION 6: Mitochondrial Mechanisms in Toxicity (Zhi Zhong, Chair)

10:15-10:40 am Mitochondrial Dysfunction in Acetaminophen Hepatotoxicity

Hartmut Jaeschke, University of Kansas Medical Center

10:40-11:05 am Mitochondrial Dysfunction in Retinal Degeneration

Baerbel Rohrer, Medical University of South Carolina

11:05-11:30 am Bak Regulates Ceramide Generation During Apoptosis: Implications for Mitochondrial Outer Membrane Permeabilization

Leah J. Siskind, Medical University of South Carolina

11:30-12:00 Poster Abstract Presentations

11:30-11:45 am The Homeobox Protein CEH-23 Mediates Longevity in Response to Mitochondrial Function in C. elegans

Walter Ludivine, Cornell University

11:45-12:00 pm ER-iPLA2y Mediates Oxidant-induced Release of Fatty Acids, Preventing ER Lip Peroxidation and Ca2+ Release

Andre Eaddy, Medical University of South Carolina

12:00-1:50 pm Lunch

2:00-4:00 pm Workshop: Metabolomics and Screening (Shannon M. Bailey, Chair)

Multianalyte Analysis

Craig C. Beeson, Medical University of South Carolina

Fusion, Fission and Obesity

Orian Shirihai, Boston University

Mitochondrial Toxicity Testing in Drug Discovery

Yvonne Will, Pfizer

Poster Abstract Presentation:

Mitochondrial Function is Impaired in an ATP13A2-Deficient Model of Parkinson’s Disease

Aaron Gusdon, University of Pittsburg School of Medicine

4:00-6:00 pm Poster Viewing (Even Numbered Posters Presenting)

6:00-9:00 pm Low Country Boil Banquet

Wednesday, November 18

7:00-7:50 am Breakfast

SESSION 7: Ischemia/Reperfusion Injury (Andrew P. Halestrap, Chair)

8:00-8:25 am Role of VDAC in Ischemia-Reperfusion Injury

Elizabeth Murphy, NIH

8:25-8:50 am Aldehyde Dehydrogenase and Protein Kinase C in Reperfusion Injury to Heart

Grant Budas, Stanford University

8:50-9:15 am Reactive Oxygen Species and Autophagy in Ischemia-Reperfusion

Jae-Sung Kim, University of Florida

9:15-9:45 am Poster Abstract Presentations

9:15-9:30 am Minocycline and Doxycycline but not Other Tetracycline-Derived Compounds, Inhibit Mitochondrial Calcium Uptake and Protect Liver Cells from Chemical Hypoxia and Ischemia/Reperfusion Injury

Justin M. Schwartz, Medical University of South Carolina

9:30-9:45 am Camkii Determines Mitochondrial Stress Responses in Heart

Mei-Ling Joiner, University of Iowa

9:45-10:10 am Break

SESSION 8: Neurodegeneration and Stroke (Chair)

10:15-10:40 am Oxidative Stress and Bioenergetic Failure in Neuronal Dysfunction

David Nicholls, Buck Institute

10:40-11:05 am Role of Cyclophilin D in Alzheimer’s Disease

Shi Du Yan, Columbia University

11:05-11:30 am Minocycline for Neuroprotection

David C. Hess, Medical College of Georgia

11:30-11:55 am PTEN-induced kinase 1 (PINK1):
Mitochondrial Quality Control in Parkinson’s Disease

Charleen T. Chu, University of Pittsburgh

11:55 am Closing Remarks

12:15 pm Lunch

DEPARTURE