Publications

SELECTED PUBLICATIONS

Paper in preparation:
Zhang N. and Wen X, Towards a “living” cochlear implant;  (In preparation; Paper is ready to be submitted. Waiting for patent application to be filed.)

Zhang N, Tresco PA, Wen X, Viability of transplanted cells can be improved by avoiding the exposure to acute or subacute inflammatory host response: Introducing an novel space creation concept for cell transplantation into brain tissue.  (In preparation)

Wright G, Zhang N, Qiu Y, Zhang C, Wen X; Induction of in vivo angiogenesis achieved by the implantation biocompatible degradable carrier that release prolyl hydroxylase inhibitors that activate the cellular oxygen-sensing pathway.  (In preparation)

Qiu Y., Zhang N, Baatz J, and Wen X, Developing a respiratory bioreactor with a dynamic cell-air interface.  (In preparation)

Qiu Y. Zhang N, Kang Q, An, Y, Wen X, Fabrication of permeable tubular constructs from chemically modified chitosan with enhanced antithrombogenic property for small-diameter vascular engineering. I: Synthesis, fabrication, characterization, and hemocompatibility.  (In preparation).

Zhang C, Zhang N, Wen X, Synthesizing a bioactive and elastic polyurethane for small blood vessel tissue engineering.  (In preparation).
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Zhang C, Zhang N, Wen X, A mini-dynamic compression bioreactor for cartilage tissue engineering.  (In preparation).

Paper under review
Zhang N. and Wen X, Hematopoietic stem cells can transdifferentiate into neural cells in vivo: a solid proof based on a bioengineering approach; Nature (Under review)

Xu T, Nichols HL, Zhang N, Wen X; Modification of Nanostructured Materials for Drug Delivery.; Acta Biomateria (Under Review)


Nichols HL, Zhang N, and Wen X, Effects of Simulated Microgravity on Human Osteoblast Behavior: A Proteomics Study, FASEBJ Journal (Under review)

Papers in press or published
Gurjarpadhye A, Hewett KW, Justus C, Wen X, Stadt H, Kirby ML, Sedmera D, Gourdie RG, Neural crest cells are necessary for insulation of the cardiac conduction system, AJP - Heart and Circulatory Physiology (Accepted)

Zhang C, Zhang N, Wen X, Synthesizing a degradable, light-curable, elastic hydrogel for cartilage tissue engineering.  (In press)

Nichols HL, Zhang N, and Wen X, Coating nano-thickness biodegradable films on nanocrystalline hydroxyapatite particles to improve the bonding strength between nanoHA and degradable polymer matrix;  (In Press).

Xu T, Zhang N, Nichols HL, Shi D, Wen X; Modification of Nanostructured Materials for Biomedical Applications.; Materials Science & Engineering C (In Press)

Zhang N. and Wen X; Fabrication of nanocrystalline hydroxyapatite doped degradable composite hollow fiber for guided and biomimetic bone tissue engineering; Materials Science & Engineering C (In press)

Nichols HL, Zhang N, and Wen X, Proteomics and Genomics of Microgravity, Physiological Genomics. 2006 Aug 16;26(3):163-71

Wen X and Tresco PA. Fabrication and Characterization of Permeable Degradable Poly(DL-Lactide-co-glycolide) (PLGA) Hollow Fiber Phase Inversion Membranes for Use as Nerve Tract Guidance Channels, Biomaterials 2006 Jul;27(20):3800-9

Wen X, Tresco PA; Effect of filament diameter and extracellular matrix molecule precoating on neurite outgrowth and schwann cell behavior on multifilament entubulation bridging device in vitro; Journal of Biomedical Materials Research: Part A. 2006 Mar 1;76(3):626-37.

Zhang C, Zhang N., and Wen X, Improving the elasticity and cytophilicity of biodegradable polyurethane by changing chain extender. Journal of Biomedical Materials Research: Part B. 2006 Nov;79(2):335-44.

Mironov V, Kasyanov V, Yost M, Visconti R, Twal W, Trusk T, Wen X, Ozolanta I, Kadishs A, Prestwich GD, Terracio L, Markwald R. Cardiovascular Tissue Engineering I. Perfusion Bioreactors: A review. Journal of Long-term Effects of Medical Implants, 16(2):111-130, 2006

An YH, Kang, QK, Wen X, Hartsock LA. Rabbit Tibial Osteomyelitis Models. MUSC Orthop Journal 9:68-71, 2006

Mironov V, Drake C, Wen X; Charleston Bioengineered Kidney Project, Biotechnol. J. 2006, 1, 903-905

Wen X and Shi D. Biomaterials, testing structural properties of.  Encyclopedia of Medical Devices and Instrumentation (2nd edition).  John Wiley & Sons, Ltd.: Hoboken, 354-365, 2006.

Wen X, and Donglu Shi.  Bioactive Ceramics: Structure, Synthesis, and Mechanical Properties, Introduction to Biomaterials. World Scientific Publishing, 13-28, 2006

Wen X, and Donglu Shi.  Bioceramic Processing, Introduction to Biomaterials. World Scientific Publishing, 29-46, 2006

Wen X, and Zhang N.  Tissue Engineering: A New Era of Regenerative Medicine, Introduction to Biomaterials. World Scientific Publishing, 207-210, 2006

Wen X, and Zhang N.  Biomaterials for Tissue Engineering, Introduction to Biomaterials. World Scientific Publishing, 211-226, 2006

Wen X, and Zhang N.  Cells and Biomolecules for Tissue Engineering, Introduction to Biomaterials. World Scientific Publishing, 227-237, 2006

Wen X, and Zhang N.  Transport and Vascularization in Tissue Engineering, Introduction to Biomaterials. World Scientific Publishing, 238-242, 2006

Wen X, and Zhang N.  Host Response to Tissue Engineered Grafts, Introduction to Biomaterials. World Scientific Publishing, 243-248, 2006

Wen X, and Zhang N.  Other Important Issues and Future Challenges in Tissue Engineering,  Introduction to Biomaterials. World Scientific Publishing, 249-253, 2006

Zhang N, Zhang C, and Wen X; Fabrication of semi-permeable hollow fiber membranes with highly aligned texture for nerve guidance; Journal of Biomedical Materials Research: Part A. 75(4):941-9, 2005

Zhang N, Yan H, and Wen X; Tissue engineering strategies for axonal guidance; Brain Research Review; 49(1), 48-64, 2005

Wen X, Shi D, and Zhang N; Applications of Nanotechnology in Tissue Engineering. Handbook of Nanostructured Biomaterials and Their Applications. American Scientific Publishers, Vol 2,393-414 2005

Massey B, Wen X, Rohr R, Tresco PA, Dahlstrom L, Park AH.  Resorption rate and biocompatibility characteristics of two polyester ventilation tubes in a guinea pig model.  Otolaryngol-Head Neck Surg J 131(6), 921-925, 2004.

Wen X and An YH: A multiple-channel scaffold for guided bone tissue engineering. MUSC Orthop J, 7: 34-38, 2004

Wen X. A new era of regenerative medicine: Tissue engineering. Frontiers in Science, InterPress Publishers: Warsaw, 1:55-75, 2003.

Shi D, Wang S, Wang L, Wen X, Qu D, Wang L, and Wang S.  Interface structure and texturing mechanism in YBCO thick films on silver alloy substrate.  Physica C 353:258-264, 2001.

Shi D, Jiang G, and Wen X.  In vitro bioactive behavior of hydroxylapatite-coated porous Al2O3; J. Biomed. Mater. Res.; Vol.53; 2000; 457-466

Wen X, Qu D, Tent BA, Shi D, Tomsic M, and White M.  Direct deposition of c-axis textured YBCO thick film on unoriented metallic substrate for the development of long superconducting tapes.  IEEE Trans Appl Superconductivity 9:1506-1509, 1999.

Shi D, Qu D, Wen X, Tent BA, and Tomsic M.  Direct peritectic growth of c-axis textured YBa2Cu3O.  J Superconduct 11:575-580, 1998.

Chen G, Wen X, and Zhang N.  Corrosion resistance and ion dissolution of titanium with different surface microroughness.  Biomed Mater Eng 8:61-74, 1998.

Zhang N, Wen X, Yan H; Biocompatibility Evaluation on Plasma Nitrided Titanium: 3. Corrosion Resistance and ion dissolution; J. of Oral Implantology of China. ; 1997, 2(1), p. 5-7

Wen X, Zhang N, Li X, and Cao Z.  Electrochemical and histomorphometric evaluation of the TiNiCu shape memory alloy. Biomed Mater Eng 7:1-11, 1997.

Chen G, Yan H, Wen X, and Zhao S; Thermodynamics studies of the protein adsorption on Titanium Implant Surfaces; J. of Oral Implantology of China. 1997, 2(3), p. 113-115

Wen X, Zhang N, and Yan H.  Histomorphometric evaluation on the biocompatibility of the TiNiCu shape memory alloy.  Chinese J Biomed Eng 14:334-339, 1997.

Wen X, Zhang N, and Yan H.  Biocompatibility evaluation on plasma nitrided titanium:  4. In vitro cell culture.  J Oral Implantol China 2:55-58, 1997.

Wen X, Zhang N, and Yan H.  Biocompatibility evaluation on plasma nitrided titanium:  5. In vivo tissue response.  J Oral Implantol China 2:59-63, 1997.

Wen X, Wang X, and Zhang N.  Microrough surface of metallic biomaterials: A literature review.  Biomed Mater Eng 6:173-189, 1996.

Zhang N, Wen X, and Yan H.  Biocompatibility evaluation on plasma nitrided titanium:  1. Surface and structure analysis and biomechanical performance.  J Oral Implantol China 1:69-72, 1996.

Zhang N, Wen X,  and Yan H; Biocompatibility Evaluation on Plasma Nitrided Titanium: 2. Hardness Distribution and Sliding Wear; J. of Oral Implantology of China.  1996, 1(2), p. 73-76

CONFERENCE PROCEEDINGS

Wen X, Biomaterial-based bridges for CNS regeneration: past, current, and future; Society for Biomaterials 33rd Annual Meeting, Chicago, IL, USA (2007)

Beachley V, Wen X; Three Dimensional Aligned Individual Nano-fibers For Neural Tissue Engineering; Society for Biomaterials 33rd Annual Meeting, Chicago, IL, USA (2007)

Zhao J, Zhang N, Scott A, Prestwich GD, Wen X;  Recruitment of Endogenous Stem Cells for Tissue Repair; Society for Biomaterials 33rd Annual Meeting, Chicago, IL, USA (2007)

Qiu Y, Zhang N, Kang Q, An Y, Wen X; Chemically Modified Light-curable Chitosans with Enhanced Potential in Bone Tissue Engineering; Society for Biomaterials 33rd Annual Meeting, Chicago, IL, USA (2007)

Wen X, Towards bioengineering of living and functional human kidney: An integration of "top down" and "bottom up' strategy. Tissue Engineering and Regenerative Medicine International Society -Europe (TERMIS-EU), Rotterdam, The Netherlands (2006)

Zhang N, Tresco PA, Wen X; A Tissue Engineered Multifilament Entubulation Bridging Device For Spinal Cord Repair; Annual Meeting of the Biomedical Engineering Society, Chicago, IL, USA (2006)

Qiu Y, Grek C, McCall R, Zhang N, Baatz JE, Wen X; A “Breathing” Respiratory Bioreactor For Studying Lung Biology And Engineering Lung Tissue; Annual Meeting of the Biomedical Engineering Society, Chicago, IL, USA (2006)

Zhao J, Taylor S, ZHang N, Mironov V, Wen X; Acceleration Of The Maturation Of Tissue Engineered Grafts By Gene Therapy; Annual Meeting of the Biomedical Engineering Society, Chicago, IL, USA (2006)

Zhao J, Zhang N, Wen X; IL-10 Expressing Stem Cells Ameliorate CNS Inflammatory Response And Improve Survival And Migration; Annual Meeting of the Biomedical Engineering Society, Chicago, IL, USA (2006)

Zhang N, Zhao J, Wen X, Hematopoietic Stem Cells Can Transdifferentiate: A Solid Proof Based On A Bioengineering Approach; Annual Meeting of the Biomedical Engineering Society, Chicago, IL, USA (2006)

Wen X, Qiu Y, Zhang N, Prestwich G,  Mironov, V; Engineering elementary structural kidney unit and demonstration its function in vivo. World Congress on Tissue Engineering and Regenerative Medicine, Pittsburgh, PA, (2006)
 
Zhang N, Zhao J, Tylor S, Wang G, Wen X; A tubular scaffold with highly aligned texture on the inner surface for small-diameter blood vessel tissue engineering: threshold for endothelial cell alignment. World Congress on Tissue Engineering and Regenerative Medicine, Pittsburgh, PA, (2006)

Zhang N, Wen X; Creating a glial scar-free implant-CNS interface by blocking chondroitin sulfate proteoglycan biosynthesis. World Congress on Tissue Engineering and Regenerative Medicine, Pittsburgh, PA, (2006)

Qiu Y, Zhang N, Kang Q, An YH, Wen X; Fabrication of Permeable Tubular Structure from Chemically Modified Chitosan with Anticoagulant Activities for Small Blood Vessel Engineering. Society for Biomaterials 32nd Annual Meeting, Pittsburgh, PA, USA (2006)

Nichols HL, Holton S, Zhang N, Wen X; Effects of Simulated Microgravity on Human Osteoblast Behavior: A Proteomics Study.Society for Biomaterials 32nd Annual Meeting, Pittsburgh, PA, USA (2006)

Long Y, Zhang C, Zhang N, Huang Y, Wen, X, Formation of highly aligned grooves on the inner surface of semi-permeable hollow fiber membrane for the directional axonal outgrowth. 2005 ASME International Mechanical Engineering Congress, Orlando, Florida USA, 2005

Zhang, N, Wright G, and Wen X, Drug-loaded degradable nano-particles for the rescue of tissues under hypoxia condition and promote angiogenesis. I. Promoting angiogenesis and reducing host inflammatory response. ACS Annual Conference, San Diego, CA, USA (2005)

Nichols HL, Zhang N, and Wen X, Guided and Biomimetic Human Long Bone Tissue Engineering. I. Coating of Nano-thickness Degradable Film on Nano-HA Particles to Improve the Properties of the Scaffold. Society for Biomaterials 31st Annual Meeting, Memphis, TN, USA (2005)

Nichols HL, Zhang N, and Wen X, Guided and Biomimetic Human Long Bone Tissue Engineering. II. Honeycomb Scaffold Fabrication and Characterization. Society for Biomaterials 31st Annual Meeting, Memphis, TN, USA (2005)

Zhang C, Zhang N, and Wen X, Fabrication of semi-permeable hollow fiber membranes with highly aligned texture for nerve guidance and tissue engineering. Society for Biomaterials 31st Annual Meeting, Memphis, TN, USA (2005)

Qiu Y, Zhang N, Wright G, and Wen X, Drug-loaded degradable nano-particles for the rescue of tissues under hypoxia condition and promote angiogenesis. Society for Biomaterials 31st Annual Meeting, Memphis, TN, USA (2005)

Wen X, and Tresco PA; Brain Tissue Response to Implanted Poly(DL-Lactide-co-Glycolide) Hollow Fiber Membranes; Society for Biomaterials 29 th Annual Meeting, Reno, NV, USA (2003)

Wen X, and Tresco PA; Biodegradable Hollow Fiber for Creating Space Within the CNS; Society for Biomaterials 28 th Annual Meeting, Tampa, FL, USA (2002)

Clark GA, Smeal RM, Kim YT, Wen X, et al; Neural Interfaces Laboratory II. Selective Activation of Small-Diameter Axons in Frog Sciatic Nerve; Society for Neuroscience's 31st Annual Meeting; San Diego, California. U.S.A. (2001)

Wen X, Webb K, and Tresco PA; Multi-filament Entubulation Bridging Device for Axonal Guidance and Regeneration; Society for Biomaterials 27 th Annual Meeting, St. Paul, MN. USA (2001)

Qu D, Tent B, Wen X, Shi D, Lu S, Ferendecii A, Selcuki E, Mast D; “Development Of High Frequency Cavity Filters Using Seeded-Melt Growth Of Single-Domain YBa2Cu3Ox Materials;” American Physical Society Centennial Meeting; Atlanta, GA (1999)

Wen X and Shi D; Direct Peritectic Deposition of YBCO on Silver Alloy Substrate; International Cryogenic Materials Conference, Montreal, Cananda.(1999)

Shi D, Qu D, Wen X, Tent B, Tomsic M; Deposition of c-axis Textured YBa2Cu3Ox on a Flexible Metallic Substrate through Direct Peritectic Solidification; The 128th TMS Annual Meeting, San Diego, California. U.S.A. (Invited paper) (1999)

Wen X, Qu D, Tent B, Shi D, Tomsic M, and White M; Direct Deposition of c-Axis Textured YBCO Thick Film on Unoriented Metallic Substrate for the Development of Long Superconducting Tapes; 1998 Applied Superconductivity Conference; Palm Desert, California. U.S.A. (1998)

Wen X, Zhang N, Seah KH, and Teoh SH; X-Ray Photoelectron Spectroscopy (XPS) Surface Analysis of Oxide of Titanium Under Different Thermal Oxidation Treatment; Society for Biomaterials 29 th Annual Meeting, San Diego, CA. U.S.A. (1998)

Wen X, Zhang N, Seah KH, and Teoh SH; Corrosion Resistance and Ion Dissolution of Titanium under Different Temperature Thermal Oxidation; 9th International Conference on Biomedical Engineering; Singapore (1997)

Zhang N and Wen X; Corrosion Resistance and ion dissolution of Titanium with Different Surface Microroughness;6th International Conference on Processing & Fabrication of Advanced Materials (PFAM-6); Singapore (1997)

Wen X, and Zhang N; A preliminary model for determining the suitable surface microroughness of specific biomaterials;6th International Conference on Processing & Fabrication of Advanced Materials (PFAM-6); Singapore (1997)

Wen X, Zhang N, et al; Electrochemical and histomorphometric evaluation of the TiNiCu shape memory alloy; 3rd Conf. on Clinical Engineering of China; pp242-249 (1996)

Wen X, Zhang N, et al; Corrosion Resistance and ion dissolution of Titanium with Different Surface Microroughness.; 3rd Conf. on Clinical Engineering of China; pp262-267 (1996)

Wen X, Zhang N., et al; Microrough Surface of Metallic Biomaterials.; 3rd Conf. on Clinical Engineering of China; pp250-261 (1996)