Wednesday, Nov. 10
4 p.m. Arrival and registration Lobby of High Hampton Inn
5 p.m. Welcome reception Wade Hampton Room
6 p.m. Opening Remarks Pavilion
6:15 p.m. Keynote Lecture Pavilion
Paul Black, Ph.D.
University of Nebraska – Lincoln
Chair & Professor of Biochemistry
“Metabolic Phenotypes Distinguish Fatty Acid Transport Protein Isoforms”
7:30-9 p.m. Dinner Dining Room
9 p.m.-12p.m. Social Time Wade Hampton Room
Thursday, Nov. 11
7:30-8:30 Breakfast Dining Room
8:30-10:15 SESSION I: Pavilion
Lipid Metabolism and Analysis
Co-chairs: Leah Siskind, Stefanka Spassieva
8:30 Sibali Bandyopadhyay, Georgia Institute of Technology
Quantitative analysis of typical ceramides and 1-deoxy-ceramides (N-acyl-1-deoxysphinganines and -1-deoxysphingosines) by reverse-phase-liquid chromatography, electrospray-ionization tandem mass spectrometry
8:45 Jeremy C. Allegood, Virginia Commonwealth University
Development of an LC-ESI-MS/MS method for the simultaneous analysis of FTY720, phospho-FTY720, sphingoid bases, and sphingoid base phosphates in cells and tissues 9:00 Abdel K. Salous, University of Kentucky
Mechanism of elimination of bioactive lipids from the circulation of live mice
9:15 Fredrick Onono, University of Kentucky
Chemical Probes reveal the mechanism of incorporation of exogenous isoprenols into proteins
9:30 Abir Mukherjee, Virginia Commonwealth University
Activation of lipogenic pathways by lysophosphatidic acid in ovarian cancer
9:45 Marisa Meyers, Medical University of South Carolina
Regulation of the Human DihydroCeramide synthase 1 (dhCerS1/LASS1) gene in HNSCC
10:00 Sarah Brice, Medical University of South Carolina
De novo sphingolipid biosynthesis by cardiac myocytes in response to free fatty acids
10:15 Coffee Break
10:30 SESSION II: Pavilion
Mechanisms of lipid signaling
Co-chairs: Christopher Clarke, Shanaka Wijesinghe
10:30 Nadia F. Lamour, Virginia Commonwealth University
The role of ceramide kinase in the production of tumor necrosis factor alpha
10:45 Aneta Dobierzewska, University of Kentucky
Regulation of IRAK-1 degradation by PP2A during IL-1B signal transduction: role of Neutral Sphingomyelinase-2
11:00 Nitai C. Hait, Virginia Commonwealth University
Nuclear Sphingosine Kinase 2 and Sphingosine-1-phosphate regulate STAT3 acetylation and transcriptional activity in breast cancer cells
11:15 Jinhua Wu, Virginia Commonwealth University
Lysophosphatidic acid signaling is a determinant of growth-inhibitory response to transforming growth factor beta in breast and ovarian cancer cells
11:30 Kuzhuvelil B. Harikumar, Virginia Commonwealth University
Sphingosine-1-phosphate: a missing player in TRAF2 mediated K63 ubiquitination of RIP1 and NF-kB activation
11:45 Brian A. Shapiro, Virginia Commonwealth University
MDA-7 exerts cytotoxic effects in A549 non-small cell lung carcinoma cells by altering the alternative splicing of Bcl-x pre-mRNA
12:00 Zachary Fulkerson and Tao Wu, University of Kentucky
The N-terminal tandem somatomedin b-like domain regulates the autotoxin/lysophospholipase D activity by interdomain interactions and integrin binding
12:25-1p.m. Lunch Dining Room
1p.m.-4p.m. Free time (hiking, canoeing, walking, golf)
4p.m.-6p.m. Poster Session Wade Hampton Room
6-6:15p.m. Presentation of Awards Pavilion
6:15-7:15 Keynote Presentation Pavilion
Susan Henry, Ph.D.
Cornell University Ronald P. Lynch Dean of the College of Agriculture and Life Sciences Professor of Molecular Biology and Genetics
Interruption of inositol sphingolipid synthesis triggers Stt4p-dependent
protein kinase C signaling
7:30-9 p.m. Dinner Dining Room
9 p.m.-12p.m. Local Entertainment and Social Time Wade Hampton Room
Friday, Nov. 12
7:30-8:30 Breakfast Dining Room
8:30-10:15 SESSION III: Pavilion
Cell biology of bioactive lipids
Co-chairs: Kauaki Takabe, Tao Wu
8:30 Kacee Sims, Georgia Institute of Technology
Kdo2-Lipid A, a TLR4 specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy
8:45 Daniel Canals, Medical University of South Carolina
Opposing regulation of ERM cytoskeletal proteins by ceramide and sphingosine-1-phosphate
9:00 Christopher J. Clarke, Medical University of South Carolina
Neutral Sphingomyelinase-2 mediates retinoic acid-induced growth arrest of MCF-7 cells by suppressing ribosomal S6 kinase and translation
9:15 Emmanual Adu-Gyamfi, Notre Dame University
Molecular Architecture of Ebola Virus Assembly
9:30 Haixia Qin, Medical College of Georgia
Caveolin-1- scaffolding domain peptide inhibits calcium-mediated mouse keratinocyte differentiation through lipid raft disruption
9:45 Patricia K. Tithof, University of Tennessee
Activation of group IVC phospholipase A2 by polycyclic aromatic hydrocarbons induces apoptosis of human coronary artery endothelial cells
10:00-10:15 Coffee Break
10:15-12:00 SESSION IV: Pavilion
Translational research in bioactive lipids
Co-Chairs: Guanghu Wang, Kimberly Paul
10:15 Sahar A. Saddoughi, Medical University of South Carolina
Targeting I2PP2A/SET oncoprotein by FTY720 relieves ceramide/I2PP2A signaling for cMyc degradation and suppression of lung tumor growth
10:30 Thamarai (Suriyan) Ponnusamy, Medical University of South Carolina
Regulation of tumor growth and metastasis by Sphingosine-1-phosphate, Sphingosine kinase in vivo
10:45 Xiaoyong Lei, University of Alabama Birmingham
Ca2+ independent phospholipase A2 (iPA2b)-regulated alternative splicing in beta-cells during the development of diabetes mellitus
11:00 Tuoyu Geng, Medical University of South Carolina
Dietary fatty acids differentially regulate hepatic steatosis in diet induced obesity through modulation of CD36 and SCD1 expression
11:15 Hujun Chen, Medical College of Georgia
Rac Activation by Lysophosphatidic Acid Determines Ovarian Cancer Metastasis
11:30 Xiaoqin Ye, University of Georgia
LPA3-receptor mediated function in female reproduction
11:45 Ding Xie, Medical College of Georgia
The potential application of phosphatidlyglycerol as a topical treatment for Psoriasis
12:00-12:15 Business Meeting Pavilion
12:15-1p.m. Lunch Dining Room
1pm Conference Adjourns
