|
 |

|
Maurizio Del Poeta, M.D.
Associate Professor |
| |
|
|
| |
2006 |
Associate
Professor, Dept. of Biochemistry and Molecular Biology,
Medical University of SC, Charleston, SC |
| |
2002 |
New
Investigator in Pathogenesis of Infectious Diseases,
Burroughs Wellcome Fund, Research Triangle Park, NC |
| |
1999-2005 |
Assistant
Professor, Dept. of Biochemistry & Molecular Biology,
Medical University of SC, Charleston, SC |
| |
1997 |
Molecular
Mycology Course, Marine Biological Laboratories, Woods
Hole, MA |
| |
1995-1999 |
Postgraduate
Training (Dr. John Perfect), Duke University Medical
Center, Durham, NC |
| |
1994-1996 |
Fellowship in
Infectious Diseases, Institute of Infectious Diseases and
Public Health, University of Ancona, Italy and Institute
of Infectious Diseases and International Health, Duke
University Medical Center, Durham, NC |
| |
1992-1994 |
Internship and
Residency in Internal Medicine, University of Ancona,
Italy |
| |
1992 |
M.D., School
of Medicine, University of Ancona, Italy |
| |
|
|
|

Office: 843-792-8381
Lab: 843-792-8764
Fax: 843-792-8565
Email: delpoeta@musc.edu
BSB-512A
click here for lab page |
|
| |
|
| |
Research Interests |
| |
The Del Poeta
laboratory studies the function of sphingolipids involved in
mediating signaling pathways and fungal pathogenesis. We have
particular interests in understanding the molecular mechanisms
by which the fungal enzyme inositol-phosphoryl ceramide
synthase (Ipc1) enables fungal organisms to cause disease.
Questions related to this area of research are addressed by
biochemical, molecular biology and patho-biological studies.
|
|
| |
Selected Publications
Click here to view list of publications on the National Library of Medicine's PubMed online database. |
| |
- Stano P, Williams V, Villani M, Cymbalyuk E, Qureshi A, Huang Y, Morace G, Luberto C, Tomlinson S, and Del Poeta M. App1: an antiphagocytic protein that binds to complement receptor 3 and 2. Journal of Immunology. In press.
- Garcia J, Shea J, Alvarez-Vasquez F, Qureshi A, Voit EO, Luberto C, Del Poeta M. 2008. Mathematical modeling of pathogenicity of Cryptococcus neoformans. Molecular System Biology. 4:183.
- Tommasino N, Villani M, Qureshi A, Henry J, Luberto C, and Del Poeta M. 2008. Atf2 transcription factor binds to App1 promoter in Cryptococcus neoformans. Stimulatory effect of diacylglycerol. Eukaryotic Cell. 7:294-301.
- Kechichian TB, Shea J, and Del Poeta M. 2007. Depletion of alveolar macrophages decreases the dissemination of a glucosylceramide deficient mutant of Cryptococcus neoformans in immunodeficient mice. Infection and Immunity. 75:4792-4798.
- Shea M, Kechichian T, Luberto C, and Del Poeta M. 2006 The cryptococcal enzyme inositol phosphospingolipid-phospholipase C (ISC1) confers resistance to the antifungal effects of macrophages and promotes fungal dissemination to the central nervous system. Infection and Immunity. 74:5977-5988.
- Rittershaus PC, Kechichian T, Allegood J, Merrill AH Jr, Hennig M, Luberto C, and Del Poeta, M. (2006)
Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans.
J. Clin. Invest., 116:1651-1659.
-
Shea JM, Kechichian TB, Luberto C, and Del Poeta, M. (2006)
The cryptococcal enzyme inositol phosphosphingolipid-phospholipase C
(ISC1) confers resistance to the antifungal effects of macrophages and promotes fungal dissemination to the central nervous system.
Infect. Immun., 74:5977-5988.
-
Shea J and Del Poeta, M. (2006)
Lipid signaling in pathogenic fungi. Current Opinion in Microbiology., 9:1-7.
-
Shea J, Henry J, and Del Poeta, M. (2006)
Lipid metabolism in Cryptococcus neoformans. FEMS Yeast Research., 6:469-479.
-
McQuiston T, Haller C., and Del Poeta, M. (2006)
Sphingolipids as targets for microbial infections. MRMC, 6:671-680.
-
Heung, LJ, Luberto, C and Del Poeta, M. (2006) The role of sphingolipids in microbial pathogenesis.
Infect. Immun., 74:28-39.
-
Mare, L., Iatta, R., Montagna,
M.T., Luberto, C. and Del Poeta, M. (2005)
Activation of App1 transcription by Ipc1-DAG is regulated by
ATF2 transcription factor in Cryptococcus neoformans.
J. Biol. Chem., 280:36055-36064.
-
Heung, L., Kaiser, A.E., Luberto,
C. and Del Poeta, M. (2005)
The role and mechanism of DAG-Pkc1 signaling in
melanogenesis by Cryptococcus neoformans. J.
Biol. Chem., 280:28547-28555.
-
Heung, L. and Del Poeta M. (2005). Unlocking the DEAD-box: a key to cryptococcal virulence? J. Clin. Invest., 115:593-595.
-
Heung, L., Luberto, C.,
Plowden, A., Hannun, Y. and Del Poeta M. (2004)
The
sphingolipid pathway regulates protein kinase C (Pkc1)
through the formation of diacylglycerol (DAG) in
Cryptococcus neoformans. J. Biol. Chem. ,
279: 21144-21153.
- Del Poeta, M. (2004)
Role of
phagocytosis in the virulence of Cryptococcus neoformans.
Eukaryotic Cell, 3:1067-1075.
- Luberto, C.,
Martinez-Marino, B., Taraskiewicz, D., Bolanos, B., Chitano,
P., Toffaletti, D.L., Cox, G.M., Perfect, J.R., Hannun, Y.A.,
Balish, E., and Del Poeta, M. (2003)
Identification of App1 as a regulator of phagocytosis and
virulence of Cryptococcus neoformans. J. Clin.
Invest., 112(7): 1080-1094.
- Cruz, M.C., Goldstein, A.L.,
Blankenship, J.R., Del Poeta, M., Davis, D.,
Cardenas, M.A., Perfect, J.R., McCusker, J.H. and Heitman,
J. (2002)
Calcineurin is essential for survival during membrane stress
in Candida albicans. EMBO J., 21(4):
546-559.
- Wills, E.A., Roberts, I.S.,
Del Poeta, M., Rivera, J., Casadevall, A., Cox, G.M.,
and Perfect, J.R. (2001)
Identification and characterization of the Cryptococcus
neoformans phosphomannose isomerase-encoding gene,
MAN1, and its impact on pathogenicity. Mol.
Microbiol. 40(3): 610-620.
- Luberto, C., Toffaletti, D.L.,
Wills, E.A., Tucker, S.C., Casadevall, A., Perfect, J.R.,
and Del Poeta, M. (2001)
Roles for inositol-phosphoryl ceramide synthase 1 (Ipc1) in
pathogenesis of C. neoformans. Genes & Dev.
15: 201-212.
- Wills, E.A., Redinbo, M.R.,
Perfect, J.R., and Del Poeta, M. (2000)
New potential targets for antifungal development.
Emerging Therapeutic Targets 4: 265-296.
- Del Poeta, M., Cruz,
M.C., Cardenas, M.E., Perfect, J.R., and Heitman, J. (2000)
Synergistic antifungal activities of bafilomycin A(1),
fluconazole, and the pneumocandin MK-0991/Caspofungin
acetate (L-743,873) with calcineurin inhibitors FK506 and
L-685,818 against Cryptococcus neoformans.
Antimicrob. Agents Chemother. 44(3): 739-746.
- Cruz, M.C., Del Poeta,
M., Wang, P., Wenger, R., Zenke, G., Quesniaux, V.F.,
Movva, N.R., Perfect, J.R., Cardenas, M.E., and Heitman, J.
(2000)
Immunosuppressive and nonimmunosuppressive cyclosporine
analogs are toxic to the opportunistic fungal pathogen
Cryptococcus neoformans via cyclophilin-dependent
inhibition of calcineurin. Antimicrob. Agents
Chemother. 44(1): 143-149.
- Del Poeta, M.,
Toffaletti, D.L., Rude, T.H., Dykstra, C.C.,
Heitman, J., and Perfect, J.R. (1999)
Topoisomerase I is essential in Cryptococcus neoformans:
Role in pathobiology and as an antifungal target.
Genetics 152: 167-178.
- Del Poeta, M.,
Toffaletti, D.L., Rude, T.H., Sparks, S.D., and
Perfect, J.R. (1999)
Cryptococcus neoformans differential gene expression
detected in vitro and in vivo with green fluorescent
protein. Infect. Immun. 67(4):
1812-1820.
- Cardenas, M.E., Cruz, M.C.,
Del Poeta, M., Chung, N., Perfect, J.R.,
and Heitman, J. (1999)
Antifungal activities of antineoplastic agents:
Saccharomyces cerevisiae as a model system to study drug
action. Clinical Microbiol. Rev.
12(4):583-611.
|
|
|