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Faculty Member Research Interests

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   Bastia, Deepak Analyses of (1) the mechanisms of initiation of DNA replication of prokaryotic plasmids and (2) the termination of DNA replication of plasmid, bacterial and yeast chromosomal, and human mitochondrial DNA
 
  Bielawska, Alicja Role of sphingolipids in signal transduction and cell regulation with emphasis on cancer biology. Specific interest is related to the regulatory function of ceramide and sphingosine-1-phosphate.
Development of molecular and analytical tools to study mechanism of biological action of sphingolipids in relation to their physicochemical properties.
 
   Bielawski, Jacek Sphingolipids in Signal Transduction
Cell Regulation in Cancer Biology
Development of new analytical protocols
 
   Bullesbach, Erika Hormones of Insulin-Like Structure:
Chemical Syntheses and Structure-Function Relations
 
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   Chao, Julie Serine Proteinase Structure-Function Relationship;
Purification, Molecular Cloning, Expression, and Function of Proteinases and Proteinase Inhibitors;
Serpin Regulation of Gene Expression
 
   Chao, Lee Nucleic Acid Biochemistry;
Regulatory Mechanism in Gene Expression;
Gene Therapy in Cardiovascular Diseases
 
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   Davies, Christopher Using X-ray crystallography to determine the structures of medically and biologically important macromolecules
 
   Del Poeta, Maurizio Role and Regulation of inositol-phosphoryl-ceramide synthase (Ipc1) in pathogenic fungi
Role and Regulation of enzymes involved in the degradation of sphingolipids
 
   Duggan, Brendan M Biological function at the molecular level biophysical techniques such as NMR, ITC and CD to characterize the three dimensional
structure and internal dynamics of biomolecules

 
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   Fernandes, Daniel Molecular mechanisms of drug-induced gene amplification
Interactions of anticancer drugs with nuclear matrix proteins, especially DNA topoisomerase II
 
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   Hama, Hiroko Lipid regulation of cellular processes
Phosphatidylinositol 4-phosphate in protein secretion
Sphingolipid hydroxylation
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accharomyces cerevisiae
 
   Hannun, Yusuf Role and Regulation of Protein Kinase C Isoenzymes
Sphingomyelin Turnover and Cellular Regulation
The Sphingomyelin/Ceramide Cycle as a Novel Target for Apoptosis and Inflammatory Disease Interventions
Ceramide Activated Protein Phosphatases
 
 
   Hansen,
Debra Tumbula


Structure and assembly of telomerase
RNA/protein complexes
   Hansen, Jeffrey L.

Study of RNA/protein complexes through x-ray crystallography; Telomerase

 

 
   Heise, Tilman

 

   
 
   Hennig, Mirko

Structural Studies of RNA-ligand complexes using NMR Spectroscopy

   
 
   Hsu, Yi-Te

Molecular mechanisms of apoptosis
Bcl-2, Bcl-X
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   Krupenko, Natalia Folate and Methyl Group Metabolism
Glycine N-Methyltransferase (GNMT)
 
   Krupenko, Sergey Protein Structure and Function
Enzyme Mechanisms and Regulation
Folate Metabolism and Carcinogenesis
 
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   Lemasters, John J
Cellular and molecular mechanisms of apoptosis and necrosis;
organ preservation for transplantation surgery;
mitochondrial physiology and pathophysiology, including mitochondrial permeability transition, mitophagy and calcium homeostasis;
oxidative stress;
ischemia/reperfusion; confocal and multiphoton microscopy of living cells.
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   Mohanty, Bidyut

Genome integrity.
DNA replication arrest-dependent homologous recombination

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   Ogretmen, Besim Roles of sphingolipid metabolism in cancer pathogenesis, chemotherapy-induced cell death, and drug resistance
 
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   Schwabe, Christian Protein Chemistry;
Biochemical Evolution;
Chemical Endocrinology
 
   
 
   Sommer, Gunhild

 

   

  

 
   Spicer, Eleanor Post Transcriptional Regulation of Bcl-2 Gene Expression;
Regulation of human oncostatin M expression;
mRNA stability

   Stillway, Bill Medical education;
Lipid metabolism
 
   Szulc, Zdzislaw Chemical etiology of sphingolipids structure and functions
 
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   Warr, Gregory Molecular Evolution,
Origins of Immune Recognition;
Immunoglobulin Gene Structure and Expression
 
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