An in-depth course emphasizing the basic metabolic reactions of living systems. Topics which are emphasized include structure-function relationship of hemoglobin, myoglobin and enzymes, pH considerations, enzymatic activity and factors such as allosteric effectors and conversion of proenzymes to active enzymes, which affect enzymatic activity, the biosynthesis (anabolism) and degradation (catabolism) of amino acids, proteins, carbohydrates, lipids, polysaccharides and nucleic acids. Topics which are covered in-depth include pH and buffers, glycolysis, the citric acid cycle, the pentose phosphate pathway, glycogen metabolism, regulation of metabolism, the nature of genetic material and the relationship of the genetic code to protein synthesis. 3 s.h. Fall.
This is an advanced course in biochemistry that emphasizes the structure/function relationships of macromolecules which comprise tissues of the oral cavity. In addition the molecular basis of certain diseases of the oral cavity, such as oral cancer, will also be covered. Topics will include collagen, calcium and fluoride metabolism, salivary proteins, immunoglobulins and blood coagulation. Students will also receive the latest information regarding the genetic alterations that lead to cancer as well as the cellular signalling pathways activated by oncogenes and tumor suppressor genes. 2 s.h. Spring.
